Publications by authors named "David Maimoun"
Invasive meningococcal disease (IMD) is a devastating disease with significant mortality and long-term morbidity. The COVID-19 pandemic and containment measures have affected the epidemiology of infectious pathogens. This study's aim was to assess IMD trends in Israel prior to and during the COVID-19 pandemic.
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- Cardiovascular diseases remain a major health issue despite the use of lipid-lowering medications, largely due to conditions like atherosclerosis, which involves inflammation and vascular remodeling.
- Research has identified cysteine protease cathepsins, particularly B, L, and S, as key players in cardiovascular inflammation and disease outcomes.
- A new non-invasive treatment method using a Photosensitizing quenched Activity-Based Probe (PS-qABP) effectively targets these enzymes and reduces inflammation in atherosclerosis, showing promise for future clinical use.
Background/aims: Atherosclerosis underlies the majority of cardiovascular events, consequent to non-resolving inflammation. Considerable evidence implicates autophagy dysfunction at the core of this inflammatory condition, but the basis of this dysfunction is not fully understood.
Methods: Using an in vitro model of lipid-laden macrophages, activity-based probes and high-throughput techniques, we studied the role of the cysteine proteases cathepsins in autophagy.