Clustering of PubMed abstracts using nearer terms of the domain.

Literature search is a process in which external developers provide alternative representations for efficient data mining of biomedical literature such as ranking search results, displaying summarized knowledge of semantics and clustering results into topics. In clustering search results, prominent vocabularies, such as GO (Gene Ontology), MeSH(Medical Subject Headings) and frequent terms extracted from retrieved PubMed abstracts have been used as topics for grouping. In this study, we have proposed FNeTD (Frequent Nearer Terms of the Domain) method for PubMed abstracts clustering.

Long-term ganciclovir therapy for hepatitis B virus infection after liver transplantation.

Background/aims: Hepatitis B virus (HBV) disease on a liver graft is associated with florid viral replication and graft failure. The aim of this study performed between 1992 and 1995 was to investigate the safety and efficacy of long-term intravenous ganciclovir for HBV infection in liver transplant recipients.

Methods: Twelve patients with HBV re-infection and four with de novo HBV infection were studied.

De novo and apparent de novo hepatitis B virus infection after liver transplantation.

Background/aims: The aim of this study was to clarify the aetiology of apparent de novo HBV infection after liver transplantation.

Methods: Twenty out of 570 HBsAg negative patients (3.5%) became HBsAg positive after transplantation and were studied.

An open trial of interferon alfa recombinant for hepatitis C after liver transplantation: antiviral effects and risk of rejection.

The aim of this open trial was to assess the efficacy and the safety of interferon (IFN) alfa therapy in liver transplant recipients with chronic active hepatitis caused by hepatitis C virus. In July 1991, among 447 liver recipients regularly observed at our institution, 46 had developed HCV-related chronic active hepatitis defined by piece meal necrosis. Fourteen of these 46 patients received IFN alfa 3 mIU three times weekly for a planned duration of 6 months and were compared to the 32 untreated patients.

Long-term clinical and virological outcome after liver transplantation for cirrhosis caused by chronic delta hepatitis.

Liver transplantation for liver diseases related to hepatitis B virus (HBV) and hepatitis delta virus (HDV) remains problematic because of the risk of viral recurrence. We report here the long-term virological outcome of patients transplanted for HDV-related liver cirrhosis (HDV cirrhosis). From December 1984 to December 1990, 76 patients with HDV cirrhosis underwent liver transplantation.

The course of hepatitis C virus infection after liver transplantation.

Hepatitis C virus-induced liver disease is becoming a main indication for liver transplantation. Recurrence of hepatitis after transplantation has been reported, but its long-term consequences are unknown. Seventy-nine patients positive for hepatitis C virus (group 1) and 106 subjects negative for hepatitis C virus antibody (group 2) with a mean follow-up of 4 yr were retrospectively studied by means of serology, nested polymerase chain reaction and branched-DNA technology before and after liver transplantation.

Pretransplantation interferon treatment and recurrence of hepatitis B virus infection after liver transplantation for hepatitis B-related end-stage liver disease.

Orthotopic liver transplantation in patients with hepatitis B-related cirrhosis is commonly complicated by reinfection with the hepatitis B virus, with rapidly progressive liver disease and poor survival rate. We assessed the efficacy of prior therapy with recombinant interferon-alpha on the prevention of posttransplantation hepatitis B virus reinfection. Twenty-two patients with hepatitis B-related cirrhosis waiting for liver transplantation received 3 MU (decreased to 1.

[Relapse prevention in liver transplant patients treated for liver involvement due to hepatitis B virus].

Controversy surrounds the indication of liver transplantation in patients with hepatitis B virus infection. The major problem is the very high risk of infection of the graft. Some investigators have suggested that the presence of HBsAg is a contraindication to liver transplantation.

Hematoma of the umbilical cord with acute antepartum fetal distress. A case report.

In a case of spontaneous hematoma of the umbilical cord, no pathologic lesion was found in the umbilical blood vessels. However, an extremely short cord (14 cm) may have contributed to the vessel rupture. A prolonged deceleration discovered during a routine nonstress test led to emergency cesarean section, with delivery of a healthy neonate.