Publications by authors named "David M Ng'ang'a"
Article Synopsis
- Preclinical studies have shown that viral vector-based HIV-1 vaccines can partially protect rhesus monkeys from challenging strains of the virus.
- In this study, priming with an adenovirus vector followed by a booster of a specific Env glycoprotein resulted in 50% of vaccinated monkeys being completely protected from SIVmac251 challenges, while all control monkeys were infected.
- The level of protection was linked to the effectiveness of the antibodies produced against the Env protein, indicating the potential of Ad/Env vaccines in preventing neutralization-resistant HIV infections.
