Increased patient comfort utilizing botulinum toxin type a reconstituted with preserved versus nonpreserved saline.

Purpose: To demonstrate that injection of botulinum toxin type A is less painful when mixed with preserved saline compared with the suggested preservative-free saline reconstitution.

Methods: Two different injections were compared on 20 patients who had prior botulinum toxin type A treatments. Each side was injected with toxin reconstituted with either preserved or nonpreserved (0.