Publications by authors named "David M Grodzki"

The outbreak of coronavirus disease 2019 (COVID-19) with the origin of the spread assumed to be located in Wuhan, China, began in December 2019, and is continuing until now. With the COVID-19 pandemic showing a progressive spread throughout the countries of the world, there is emerging interest for the potential long-term consequences of suffering from a COVID-19 pneumonia. Imaging plays a central role in the diagnosis and management of COVID-19 pneumonia, with chest X-ray examinations and computed tomography (CT) being undoubtedly the modalities most widely used, allowing for a fast and sensitive detection of infiltration patterns associated with COVID-19 pneumonia.

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Objective: The aim of this study was to investigate acoustic noise reduction and image quality of cranial magnetic resonance imaging (MRI) at 7T MRI with and without sequence-based acoustic noise reduction.

Materials And Methods: Fifteen patients and 5 healthy volunteers underwent 7T MRI scanning. A fluid-attenuated inversion recovery (FLAIR) sequence was acquired with and without sequence-based acoustic noise reduction.

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Objective: Purpose of our study was to demonstrate the feasibility and limitations of acoustic noise reduction in a standard clinical MRI protocol for abdominal imaging.

Methods: Acoustic noise and image quality were assessed in 17 patients for a standard liver imaging protocol including TSE and GRE sequences and compared to quiet optimizations as described by Heismann et al. Two blinded readers scored artifacts, the delineation of the abdominal organs and level of diagnostic confidence.

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Purpose: To compare the quality and diagnostic value of routine single-shot, echo-planar imaging, diffusion-weighted imaging (ss-EPI-DWI) to those of quiet readout segmented EPI-DWI (q-DWI) in magnetic resonance imaging (MRI) of acute stroke.

Materials And Methods: Twenty-six patients with acute stroke underwent a 1.5T MRI including diffusion-weighted ss-EPI and q-DWI.

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Purpose: Panoramical radiographs or cone-beam computed tomography (CT) are the standard-of-care in dental imaging to assess teeth, mandible, and mandibular canal pathologies, but do not allow assessment of the inferior alveolar nerve itself nor of its branches. We propose a new technique for "MR neurographic orthopantomograms" exploiting ultrashort echo-time (UTE) imaging of bone and teeth complemented with high-resolution morphological and functional MR neurography.

Materials And Methods: The Institutional Review Board approved the study in 10 healthy volunteers.

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Objective: This work was aimed at reducing acoustic noise in diffusion-weighted MR imaging (DWI) that might reach acoustic noise levels of over 100 dB(A) in clinical practice.

Materials And Methods: A diffusion-weighted readout-segmented echo-planar imaging (EPI) sequence was optimized for acoustic noise by utilizing small readout segment widths to obtain low gradient slew rates and amplitudes instead of faster k-space coverage. In addition, all other gradients were optimized for low slew rates.

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Objectives: This study sought to compare various 3D cartilage sequences and to evaluate the usefulness of ultrashort TE (UTE) imaging, a new technique to isolate signal from the osteochondral junction.

Methods: Twenty knees were examined at 3 T with 3D spoiled GRE (FLASH), double-echo steady-state (DESS), balanced SSFP, 3D turbo spin-echo (TSE), and a prototype UTE sequence. Two radiologists independently evaluated all images.

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Accurate separation of air and bone is critical for creating synthetic CT from MRI to support Radiation Oncology workflow. This study compares two different ultrashort echo-time sequences in the separation of air from bone, and evaluates post-processing methods that correct intensity nonuniformity of images and account for intensity gradients at tissue boundaries to improve this discriminatory power. CT and MRI scans were acquired on 12 patients under an institution review board-approved prospective protocol.

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Purpose: To quantify the accuracy of three-dimensional (3D) radial arterial spin labeled (ASL) magnetic resonance angiography (MRA) using vascular models of carotid stenosis.

Methods: Eight vascular models were imaged at 1.5 Tesla using pulsatile flow waveforms at rates found in the internal carotid arteries (100-400 mL/min).

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Purpose: To compare the lesion contrast and signal to noise ratio (SNR) obtained with T1-weighted pointwise encoding time reduction with radial acquisition (PETRA) to those of Magnetization-Prepared RApid Gradient-Echo (MPRAGE) for contrast-enhanced imaging of primary and metastatic intracranial tumors, and to investigate whether PETRA is able to reduce acoustic noise for improved patient comfort.

Materials And Methods: Fifteen patients with intracranial tumors underwent 3 Tesla MRI including inversion-prepared PETRA and MPRAGE. The two sequences had comparable scan times, spatial resolution and spatial coverage.

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Many MRI sequences use non-selective hard pulse excitation in the presence of imaging gradients. In this work, we investigate to which extent the sinc-shaped frequency excitation profiles of the pulse can be used for imaging without the generation of artefacts. A correction algorithm is proposed that eliminates the influence of the excitation profile.

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Sequences with ultrashort echo times enable new applications of MRI, including bone, tendon, ligament, and dental imaging. In this article, a sequence is presented that achieves the shortest possible encoding time for each k-space point, limited by pulse length, hardware switching times, and gradient performance of the scanner. In pointwise encoding time reduction with radial acquisition (PETRA), outer k-space is filled with radial half-projections, whereas the centre is measured single pointwise on a Cartesian trajectory.

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