Chromosomal Instability Causes Sensitivity to Polyamines and One-Carbon Metabolism.

Aneuploidy, or having a disrupted genome, is an aberration commonly found in tumours but rare in normal tissues. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift, which makes these cells sensitive to internal and environmental stresses. Using as a model, we investigated the changes in transcription in response to ongoing changes to ploidy (chromosomal instability, CIN).

Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis.

Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa.

The impact of aneuploidy on cellular homeostasis.

Genomic instability is a common feature of tumours that has a wide range of disruptive effects on cellular homeostasis. In this review we briefly discuss how instability comes about, then focus on the impact of gain or loss of DNA (aneuploidy) on oxidative stress. We discuss several mechanisms that lead from aneuploidy to the production of reactive oxygen species, including the effects on protein complex stoichiometry, endoplasmic reticulum stress and metabolic disruption.

Theory of weak bipolar fields and electron holes with applications to space plasmas.

A theoretical model of weak electron phase-space holes is used to interpret bipolar field structures observed in space. In the limit ephi(max)/Te << 1 the potential of the structure has the unique form, phi(x) = phi(max)sech4(x/alpha), where phi(max) depends on the derivative of the trapped distribution at the separatrix, while alpha depends only on a screening integral over the untrapped distribution. Idealized trapped and passing electron distributions are inferred from the speed, amplitude, and shape of satellite waveform measurements of weak bipolar field structures.