Publications by authors named "David L Figueiredo"
Laryngeal squamous cell carcinoma (LSCC) is a very aggressive cancer, considered to be a subtype of the head and neck squamous cell carcinoma (HNSCC). Despite significant advances in the understanding and treatment of cancer, prognosis of patients with LSCC has not improved recently. In the present study, we sought to understand better the genetic mechanisms underlying LSCC development.
View Article and Find Full Text PDFArticle Synopsis
- Laryngeal squamous cell carcinoma (LSCC) is a prevalent type of head and neck cancer often linked to lifestyle choices like smoking and drinking.
- A study was conducted involving gene expression profiling of 31 patients diagnosed with LSCC to identify potential new targets that might be involved in the development of this cancer.
- The research aims to enhance the understanding of LSCC biology and potentially lead to better treatment strategies.
Larynx cancer is the second most common type of cancer among all head and neck cancers. Deregulation of epigenetic effectors, including altered expression of histone methyltransferases from the MLL (mixed lineage leukemia) family, have been reported in many cancer types, yet little is known concerning their involvement in larynx cancer. Our objective was to determine the expression profile of MLL genes in larynx carcinoma and normal adjacent tissues and correlate this profile to tumor characteristics.
View Article and Find Full Text PDFHuman papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection.
Cancer Causes Control
April 2014
Article Synopsis
- - The study investigates the impact of HPV16 on survival rates in Brazilian patients with head and neck squamous cell carcinoma (HNSCC), particularly in regions where HPV prevalence is low.
- - Researchers analyzed data from a cohort of 1,093 HNSCC patients, identifying a higher prevalence of HPV16 antibodies in oropharyngeal cancer compared to other sites, and linking the presence of these antibodies to improved survival outcomes.
- - The findings suggest that patients with oropharyngeal squamous cell carcinoma who test positive for HPV16 E6/E7 antibodies have a significantly lower risk of death, indicating that these antibodies could serve as a useful prognostic marker for this type of cancer.
Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients.
Clinics (Sao Paulo)
June 2013
Article Synopsis
- The study investigates how smoking and alcohol consumption habits affect squamous cell carcinoma characteristics in a Brazilian cohort.
- A total of 1,633 patients were analyzed, revealing that smokers and drinkers tended to be younger and leaner, while non-smokers/non-drinkers were often elderly women with better cancer differentiation.
- Findings indicate that alcohol consumption is linked to more frequent nodal metastasis, while smoking is associated with less differentiated tumors, highlighting significant demographic and clinical differences based on lifestyle choices.
Unlabelled: Many studies have reported increased expression of S100 A7 (psoriasin) in neoplastic lesions. Among them are studies on breast carcinoma, bladder squamous cell carcinoma, skin tumors and oral cavity squamous cell carcinoma. The expression of S100 A7 has not been described for laryngeal cancer.
View Article and Find Full Text PDFBackground: Tumor markers are genes or their products expressed exclusively or preferentially in tumor cells and cancer-testis antigens (CTAs) form a group of genes with a typical expression pattern expressed in a variety of malignant neoplasms. CTAs are considered potential targets for cancer vaccines. It is possible that the CTA MAGE-A4 (melanoma antigen) and MAGE-C1 are expressed in carcinoma of the oral cavity and are related with survival.
View Article and Find Full Text PDFBackground: A subset of thyroid tumors characterized by a follicular growth pattern can represent a serious diagnosis. Immunohistochemistry and molecular pathology for genetic profiling have been used in an attempt to resolve some of these issues.
Methods: Tumor tissue samples of thyroid were obtained from 70 patients who underwent surgical therapy.
Background: Despite diagnostic and therapeutic advances in head and neck cancer, the 5-year survival of patients with laryngeal cancer has not improved in the last 30 years. Several recent studies indicate that specific targets for immunotherapeutic approaches can be useful in the control of cancer. There is considerable interest in the expression of cancer testis antigens in human cancers since they may serve as the basis for an immunologic approach to therapy.
View Article and Find Full Text PDFBackground: There is considerable interest in the expression of cancer testis (CT) antigens in human cancers, because they may serve as the basis for diagnostic tests or an immunologic approach to therapy, or as prognostic markers.
Methods: On this basis, we evaluated by semiquantitative reverse-transcriptase polymerase chain reaction (RT-PCR) the expression of genes that code for tumor antigens (melanoma antigen-1 [MAGE-1], MAGE-4, MAGE-10, MAGE-12, B melanoma antigen, CTL-recognized antigen melanoma antigen (CT antigen 2) [LAGE], New York esophageal squamous cell carcinoma antigen (CT antigen 1) [NYESO-1], and preferentially expressed antigen of melanoma [PRAME]) in surgical samples of the tumors, margins, and lymph nodes (when present) from patients with a diagnosis of head and neck carcinoma. The study was conducted on 33 patients (31 men and two women), aged 31 to 94 years (mean, 56 years), with squamous cell carcinomas located in the mouth (15 cases), larynx (14 cases), and pharynx (four cases).