Publications by authors named "David Kuntin"
Signalling through TNFR1 modulates proinflammatory gene transcription and programmed cell death, and its impairment causes autoimmune diseases and cancer. NEDD4-binding protein 1 (N4BP1) is a critical suppressor of proinflammatory cytokine production that acts as a regulator of innate immune signalling and inflammation. However, our current understanding about the molecular properties that enable N4BP1 to exert its suppressive potential remain limited.
View Article and Find Full Text PDFMesenchymal stem cells are as fascinating as they are enigmatic. They appear capable of performing a wide array of functions that cross skeletal biology, immunology and haematology. As therapeutics, mesenchymal stem cells or even just their secreted products may be used to regenerate tissue lost through injury or disease and suppress damaging immune reactions.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how bone marrow mesenchymal stem/stromal cells (MSCs) can maintain bone health and repair through signaling pathways, revealing a new signaling mechanism regulated by epidermal growth factor (EGF).
- - EGF activates β-catenin, a vital part of the Wnt signaling pathway, causing it to move to the nucleus, but does not affect Wnt target gene expression or T cell factor activity in MSCs.
- - Using statistical analysis and RNA sequencing, the researchers found that EGF and β-catenin signaling work together to enhance MSC proliferation by relieving cell cycle pathway suppression from traditional EGF signaling.