Publications by authors named "David Kruger"

The Chinese yam (, DP) is promising for the food and pharmaceutical industries due to its nutritional value and pharmaceutical potential. Its proper cultivation is therefore of interest. An insufficient supply of minerals necessary for plant growth can be manifested by discoloration of the leaves.

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The ongoing development of bacterial resistance to antibiotics is a global challenge. Research in that field is thus necessary. Analytical techniques are required for such a purpose.

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Background: Patient-reported outcome measures are essential tools in clinical decision-making and research. Multi-item scores like the modified Harris Hip Score (mHHS) are time-consuming to collect and evaluate. The subjective hip value (SHV), as a single-item value, assesses hip function with one question: "What is the overall percent value of your hip if a completely normal hip represents 100%?".

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The Chinese yam (, DP) is known for the nutritional value of its tuber. Nevertheless, DP also has promising pharmacological properties. Compared with the tuber, the leaves of DP are still very little studied.

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Abductor deficiency after total hip arthroplasty is a severe complication with functional limitations and a significant reduction in the patient's quality of life. Common causes are degenerative ruptures or approach-related iatrogenic damage to the gluteus medius and minimus muscle and the inferior gluteal nerve, fractures of the greater trochanter and incorrect reconstruction of leg length and femoroacetabular offset. With a standardised diagnosis consisting of a clinical examination, conventional X-ray and MRI, the causes of the functional problems can often be reliably determined.

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We study a generic model of a Chern insulator supplemented by a Hubbard interaction in arbitrary even dimension D and demonstrate that the model remains well defined and nontrivial in the D→∞ limit. Dynamical mean-field theory is applicable and predicts a phase diagram with a continuum of topologically different phases separating a correlated Mott insulator from the trivial band insulator. We discuss various features, such as the elusive distinction between insulating and semimetal states, which are unconventional already in the noninteracting case.

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Introduction: The effect of different bearings on synovial white blood cell (WBC) count and polymorphonuclear percentage (PMN%) in aspirations remains unclear. Therefore, this study investigates the impact of aseptic Metal-on-Metal (MoM) bearing on synovial fluid.

Methods: We searched our arthroplasty registry for aseptic painful THAs with MoM bearings between 2011 and 2018.

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Introduction: The correct moment for return to driving after total hip arthroplasty (THA) remains unclear. Until today no uniform recommendation exists on the ability to perform an emergency brake.The aim of this prospective study was to investigate the braking ability of patients before and after THA implantation based on brake reaction time in milliseconds (BRT) and braking force in N (BF).

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Background: The optimal treatment of anteroinferior glenoid rim fractures remains a matter of debate. Surgical repair aims to prevent persistent instability and osteoarthritic changes of the glenohumeral joint and is recommended in patients with a subluxated humeral head and substantial displacement of the fracture fragment(s). Arthroscopic reconstruction with suture anchors was described by Sugaya et al.

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Heterogeneous populations of human bone marrow-derived stromal cells (BMSC) are among the most frequently tested cellular therapeutics for treating degenerative and immune disorders, which occur predominantly in the aging population. Currently, it is unclear whether advanced donor age and commonly associated comorbidities affect the properties of -expanded BMSCs. Thus, we stratified cells from adult and elderly donors from our biobank ( = 10 and = 13, mean age 38 and 72 years, respectively) and compared their phenotypic and functional performance, using multiple assays typically employed as minimal criteria for defining multipotent mesenchymal stromal cells (MSCs).

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Background: Most children experience pain in hospitals; and their parents report dissatisfaction with how well pain was managed. Engaging patients and families in the development and evaluation of pain treatment plans may improve perceptions of pain management and hospital experiences.

Objectives: The aim of this performance improvement project was to engage patients and families to address hospitalized pediatric patients' pain using interactive patient care technology.

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Besides the known intraarticular femoroacetabular impingement (FAI), recently forms of extra-articular impingement of the hip have been increasingly recognized. Recent studies have described an extra-articular impingement between a distal extension of the anterior inferior iliac spine (AIIS) and the femoral neck (AIIS or subspine impingement). Evidently, an association between this subspine impingement and an intraarticular FAI seems to exist.

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Primary septic arthritis is a rare differential diagnosis of acute hip pain in adults. Inspired by the success of all-arthroscopic treatment in pediatric patients, we developed a diagnostic and surgical pathway for our adult patients. Seven patients, average age 44 ± 13.

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Article Synopsis
  • - The study focuses on femoroacetabular impingement (FAI) and examines whether arthroscopic surgery improves patient outcomes in the mid- to long-term, given the uncertainty about its effectiveness in preventing joint degeneration.
  • - A retrospective analysis of 50 patients was conducted, measuring preoperative and follow-up scores such as the modified Harris hip score (mHHS), WOMAC index, and subjective hip value (SHV), alongside radiographic assessments of joint degeneration.
  • - Results showed significant improvements in mHHS and α angle measurements after surgery, indicating better hip function, though the Kellgren and Lawrence score showed no significant change, and 5 patients eventually required total hip arthroplasty.
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Background: The macroscopic pathomorphology in recurrent shoulder instability has been described. However, less is known regarding the histopathologic details of the affected structures. This study evaluates different histopathologic stages of shoulder instability by assessing biopsy specimens of static stabilizers for possible correlations with clinical parameters.

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Administration of endothelial progenitor cells (EPC) is a promising therapy for post-infarction cardiac repair. However, the mechanisms that underlie apparent beneficial effects on myocardial remodeling are unclear. In a porcine model of acute myocardial infarction, we investigated the therapeutic effects of a mixed population of culture modified peripheral blood mononuclear cells (termed hereafter porcine EPC).

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The relative signal-to-noise ratio (SNR) provided by 2D sensitivity encoding (SENSE) when applied to 3D contrast-enhanced MR angiography (CE-MRA) is studied. If an elliptical centric phase-encoding order is used to map the waning magnetization of the contrast bolus to k-space, the application of SENSE will reduce the degree of k-space signal modulation, providing a signal amplification A over corresponding nonaccelerated acquisitions. This offsets the SNR loss in R-accelerated SENSE due to suquare root R and the geometry (g) factor.

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Article Synopsis
  • The study examined the effects of a pacing model of heart failure on regional changes in cardiotrophin-1 (CT-1) and heart function measured through MRI in dogs.
  • After heart failure induction, both the left ventricular ejection fraction and end-diastolic volume showed significant changes compared to baseline, indicating altered heart function.
  • The results revealed that CT-1 levels and minimum principal strain (MPS) varied significantly in the inferior and septal walls near the pacemaker site, potentially explaining myocyte hypertrophy and improved function in these areas.
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Informed consent was obtained; the study was HIPAA compliant and institutional review board approved. Fourfold accelerated (FFA) two-dimensional (2D) sensitivity encoding (SENSE) (65 seconds) was prospectively compared with its nonaccelerated counterpart (4 minutes 20 seconds) for diagnostic image quality and sharpness of visualization of blood vessels at 1.5 T with three-dimensional (3D) intracranial contrast-enhanced magnetic resonance venography in 18 consecutive volunteers (10 men, eight women; mean age, 48.

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This study was approved by the institutional review board and was HIPAA compliant. All subjects provided written informed consent, and subject confidentiality was protected. The purpose of this study was to prospectively evaluate the feasibility of integrating a modified elliptical centric (EC) acquisition with a continuously moving table technique to acquire high-spatial-resolution contrast material-enhanced magnetic resonance (MR) angiograms of the peripheral vasculature.

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Time-resolved continuously moving table imaging techniques have been previously developed to observe a dynamically changing phenomenon over an extended field-of-view. The acquisition involves differential k-space sampling and view sharing. Since the table is continuously moving during data acquisition, the k-space for any longitudinal position is sampled only sparsely for the first reconstruction timeframe and is progressively more fully sampled for subsequent frames.

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Sensitivity encoding (SENSE) and partial Fourier (PF) techniques both reduce MRI acquisition time. Two-dimensional SENSE uses coil sensitivities to unfold aliasing in the phase/slice-encoding plane. One-dimensional PF and homodyne reconstruction are routinely applied in the frequency/phase-encoding plane to compensate for nonsampled k-space of the presumed real magnetization.

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Although contrast-enhanced MR angiography (CE-MRA) has been successfully developed into a routine clinical imaging technique, there is still need for improved spatial resolution in a given acquisition time. Undersampled projection reconstruction (PR) techniques maintain spatial resolution with reduced scan times, and the elliptical centric (EC) view order provides high quality arterial phase images without venous contamination. In this work, we present a hybrid elliptical centric-projection reconstruction (EC-PR) technique to provide spatial resolution improvement over standard EC in a given time.

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An integration of SENSitivity Encoding (SENSE) with continuously moving table (CMT) MRI for extended field-of-view (FOV) acquisitions is described. In this work, the approach in which receiver coils are attached to the object and move in synchrony with the scanner table is considered. Technical issues dealing with the implementation of SENSE-CMT are addressed, including coil calibration, correction for non-uniform magnetic gradients, and specific reconstruction steps.

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