Publications by authors named "David Kikaawa"
J Biomol Struct Dyn
October 2024
Article Synopsis
- Leishmaniasis treatment currently relies on chemotherapy due to the absence of vaccines, with existing drugs facing challenges like low effectiveness, resistance, and toxicity, highlighting the need for safer alternatives.
- Research on benzo[c]phenanthridines revealed strong antileishmanicidal activity, particularly with 10-isopropoxy sanguinarine demonstrating the highest binding affinity to the target enzyme nucleoside diphosphate kinase (NDPK).
- Further analysis identified specific molecular targets and pathways involved in leishmaniasis, with 2D and 3D-QSAR models validating the potential of these compounds as effective treatments.
