Thermal buffering-controlled temperature variation between Mg-Al-rich rocks and migmatites.

It is well recognised that endothermic processes such as dehydration and partial melting have the potential to exert measurable effects on the maximum temperatures reached in metamorphic rock systems. We show migmatitic metapelitic and mafic granulites record temperatures of ~ 820 °C, while spatially associated refractory Mg-Al-rich granulites record temperatures between 865 °C and > 920 °C. These thermally contrasting samples are separated by ~ 1500 m, with no apparent intervening faults or shear zones to explain the apparent difference in peak metamorphic conditions.

Avoidance Behaviours and Missed Opportunities in a Case of Metastatic Squamous Cell Carcinoma.

We describe the case of a 96-year-old woman who presented with a large fungating squamous cell carcinoma on her neck. In the Western hemisphere, it is rare to see patients with advanced tumours at their first presentation. We summarise the events leading to her late presentation to the hospital and explore the contributing factors.

Laboratory validation of a low density lipoprotein apolipoprotein-B assay.

Objectives: Numerous publications have shown strong association between CHD risk and either apolipoprotein B (Apo-B) or low density lipoprotein (LDL) particle number (LDL-P). It is however unknown if Apo-B or LDL-P has a stronger predictive ability for future CHD. This uncertainty may be due to the inability of current Apo-B assays to separate the contribution of very low-density lipoprotein particles from the total Apo-B concentration.

Negative differential mobility of weakly driven particles in models of glass formers.

We study the response of probe particles to weak constant driving in kinetically constrained models of glassy systems, and show that the probe's response can be nonmonotonic and give rise to negative differential mobility: increasing the applied force can reduce the probe's drift velocity in the force direction. Other significant nonlinear effects are also demonstrated, such as the enhancement with increasing force of the probe's fluctuations away from the average path, a phenomenon known in other contexts as giant diffusivity. We show that these results can be explained analytically by a continuous-time random walk approximation where there is decoupling between persistence and exchange times for local displacements of the probe.