Publications by authors named "David Kakish"
Background: Lipoleiomyomas are uncommon uterine lesions containing adipose and smooth muscle tissue. They have a variable presentation and are usually found incidentally on imaging or post-hysterectomy tissue analysis. Given their low prevalence, there is a dearth of literature describing imaging characteristics for uterine lipoleiomyomas.
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- Hepatosplenomegaly is typically diagnosed by examining size measurements, but using volumetric assessments can lead to more accurate diagnoses of liver and spleen enlargement.
- Artificial intelligence, specifically convolutional neural networks (CNNs), has been employed to automatically segment and measure liver and spleen volumes from a large dataset of CT scans, achieving high accuracy when compared to manual measurements.
- The study found significant differences in liver and spleen volumes between genders, leading to sex-specific thresholds for diagnosing hepatomegaly and splenomegaly, with the CNNs outperforming radiologist assessments in accuracy and diagnostic performance.
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- The study analyzes the impact of COVID-19 on trauma volumes and CT exams at a Level-I trauma center, focusing on three time periods: pre-pandemic, during COVID safety measures, and after those measures were eased.
- Findings show a significant increase in daily trauma patient volumes and the number of CT exams performed after restrictions were lifted, with trauma cases rising from an average of 10.3 during COVID times to 13.9 in the POST period.
- The average turnaround time for trauma CT examinations also increased significantly, highlighting a strain on healthcare services even as patient volume recovers post-pandemic.
Hemimegalencephaly, or unilateral megalencephaly, is a sporadic congenital brain malformation characterized by enlargement of a cerebral hemisphere due to an abnormal proliferation of neurons or glial cells. Hemimegalencephaly is part of a spectrum of disorders, increasingly referred to as mTORopathies, which arise as a result of dysregulation or hyperactivation of the mammalian target of rapamycin (mTOR)-signaling cascade resulting in less restricted cell growth and survival. The resultant cortical disorganization and enhanced neuronal excitability often manifest clinically in the form of seizures.
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