Publications by authors named "David Junk"
Background: Malrotation of the bowel due to imperfect embryologic development is a rare condition with a wide spectrum of resulting anatomical variations. Similar conditions are achieved in the adult by derotating the bowel via the Cattell-Braasch maneuver. However, possible preparational bias might compromise the resulting topography.
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- Current immunotherapies for non-small cell lung cancer (NSCLC) lack effective ex vivo models to predict individual patient responses, particularly for therapies with moderate effectiveness.
- A new standardized ex vivo tissue culture model was developed that preserves tumor characteristics and T-cell function for several days, allowing for the analysis of responses to the PD-1 inhibitor nivolumab.
- The study found correlations between T-cell responses and clinical outcomes, suggesting that this model can help stratify patients for better treatment selection and deepen understanding of tumor-associated T-cell regulation.