Intracranial volume in patients with nonsyndromal craniosynostosis.

Object: In recent years, comparisons between intracranial volumes (ICVs) in patients with craniosynostosis and healthy patients have given variable results, leading to questions regarding the validity of the normal reference material and the comparability of the measurement techniques. In this study, ICVs in patients with nonsyndromal craniosynostosis without previous surgical intervention were compared with the ICVs of a normal population of European descent determined using the same method for each group.

Methods: Determination of ICV was based on measuring the area of intersection in each computerized tomography slice.