Publications by authors named "David Jl Yu"
Article Synopsis
- The rise of autoimmune diseases calls for new therapies, but there's a lack of long-term evaluation methods for these treatments.
- Researchers used advanced techniques to analyze the unique patterns of autoantibodies in individuals, identifying stable "autoreactomes" that serve as immunological fingerprints.
- Their findings suggest that therapies targeting B cell maturation antigen (BCMA) can significantly change these autoreactomes, implying that BCMA-based treatments might be effective for difficult-to-treat autoimmune conditions.
Article Synopsis
- The rise of autoimmune diseases and related disorders is significant globally, but the underlying causes are still unclear, and there is a lack of comprehensive methods to evaluate new immunomodulatory treatments over time.
- Researchers used advanced PhIP-Seq technology to study how autoantibody profiles, which are unique to each individual, change in health and disease, identifying a stable immunological fingerprint known as the "autoreactome."
- The study found that certain therapies, specifically those targeting B-Cell Maturation Antigen (BCMA), have a major impact on autoantibody profiles, while others like anti-CD19 and CD-20 have minimal influence, suggesting BCMA-targeted therapies may be more effective in treating autoantibody-mediated diseases.
