Publications by authors named "David Javier Apam-Castillejos"

Article Synopsis
  • Dendritic spine pathology involves changes in the structure and density of dendritic spines in neurons, which are important for understanding schizophrenia's neurobiological aspects, particularly in the corticolimbic system.
  • A model using neonatal ventral hippocampus lesions in rats mirrors schizophrenia symptoms and related dendritic spine changes; atypical antipsychotic drugs like risperidone and olanzapine can help alleviate these issues.
  • The research shows that these drugs increase dendritic spine density and the beneficial mushroom spine type while reducing less favorable stubby spines, highlighting the crucial role of neuroplasticity in the temporal lobe for schizophrenia treatments.
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Schizophrenia is a neurodevelopmental disorder characterized by a loss of dendritic spines in the medial prefrontal cortex (mPFC). Multiple subclinical and clinical studies have evidenced the ability of antipsychotics to improve neuroplasticity. In this study, it was evaluated the effect of the atypical antipsychotic aripiprazole (ARI) on the behavioral and mPFC neuronal disturbances of rats with neonatal ventral hippocampus lesion (nVHL), which is a heuristic developmental model relevant to the study of schizophrenia.

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Second-generation antipsychotics are the drugs of choice for the treatment of neurodevelopmental-related mental diseases such as schizophrenia. Despite the effectiveness of these drugs to ameliorate some of the symptoms of schizophrenia, specifically the positive ones, the mechanisms beyond their antipsychotic effect are still poorly understood. Second-generation antipsychotics are reported to have anti-inflammatory, antioxidant and neuroplastic properties.

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