Publications by authors named "David J Yu"

A useful theoretical lens that has emerged for understanding urban resilience is the four basic types of interdependencies in critical infrastructures: the physical, geographic, cyber, and logical types. This paper is motivated by a conceptual and methodological limitation-although logical interdependencies (where two infrastructures affect the state of each other via human decisions) are regarded as one of the basic types of interdependencies, the question of how to apply the notion and how to quantify logical relations remains under-explored. To overcome this limitation, this study focuses on institutions (rules), for example, rules and planned tasks guiding human interactions with one another and infrastructure.

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Article Synopsis
  • The rise of autoimmune diseases calls for new therapies, but there's a lack of long-term evaluation methods for these treatments.
  • Researchers used advanced techniques to analyze the unique patterns of autoantibodies in individuals, identifying stable "autoreactomes" that serve as immunological fingerprints.
  • Their findings suggest that therapies targeting B cell maturation antigen (BCMA) can significantly change these autoreactomes, implying that BCMA-based treatments might be effective for difficult-to-treat autoimmune conditions.
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Article Synopsis
  • The rise of autoimmune diseases and related disorders is significant globally, but the underlying causes are still unclear, and there is a lack of comprehensive methods to evaluate new immunomodulatory treatments over time.
  • Researchers used advanced PhIP-Seq technology to study how autoantibody profiles, which are unique to each individual, change in health and disease, identifying a stable immunological fingerprint known as the "autoreactome."
  • The study found that certain therapies, specifically those targeting B-Cell Maturation Antigen (BCMA), have a major impact on autoantibody profiles, while others like anti-CD19 and CD-20 have minimal influence, suggesting BCMA-targeted therapies may be more effective in treating autoantibody-mediated diseases.
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It is puzzling how altruistic punishment of defectors can evolve in large groups of nonrelatives, since punishers should voluntarily bear individual costs of punishing to benefit those who do not pay the costs. Although two distinct mechanisms have been proposed to explain the puzzle, namely voluntary participation and group-level competition and selection, insights into their joint effects have been less clear. Here we investigated what could be combined effects of these two mechanisms on the evolution of altruistic punishment and how these effects can vary with nonparticipants' individual payoff and group size.

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Understanding of how anthropogenic droughts occur in socio-hydrological systems is critical in studying resilience of these systems. This is especially relevant when a "lock-in" toward watershed desiccation occurs as an emergent outcome of coupling among social dynamics and surface and underground water processes. How the various processes collectively fit together to reinforce such a lock-in and what may be a critical or ignored feedback worsening the state of the socio-hydrological systems remains poorly understood.

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With increasing flood risk, evacuation has become an important research topic in urban flood management. Urban flood evacuation is a complex problem due to i) the complex interactions among several components within a city and ii) the need to consider multiple, often competing, dimensions/objectives in evacuation analysis. In this study, we focused on the interplay between two such objectives: efficiency and fairness.

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The Sustainable Development Goals (SDGs) of the United Nations Agenda 2030 represent an ambitious blueprint to reduce inequalities globally and achieve a sustainable future for all mankind. Meeting the SDGs for water requires an integrated approach to managing and allocating water resources, by involving all actors and stakeholders, and considering how water resources link different sectors of society. To date, water management practice is dominated by technocratic, scenario-based approaches that may work well in the short term but can result in unintended consequences in the long term due to limited accounting of dynamic feedbacks between the natural, technical, and social dimensions of human-water systems.

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Maintaining the performance of infrastructure-dependent systems in the face of surprises and unknowable risks is a grand challenge. Addressing this issue requires a better understanding of enabling conditions or principles that promote system resilience in a universal way. In this study, a set of such principles is interpreted as a group of interrelated conditions or organizational qualities that, taken together, engender system resilience.

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The use of shared infrastructure to direct natural processes for the benefit of humans has been a central feature of human social organization for millennia. Today, more than ever, people interact with one another and the environment through shared human-made infrastructure (the Internet, transportation, the energy grid, etc.).

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