Publications by authors named "David J Tanous"
The relationship between exercise capacity and right ventricular (RV) structure and function in adult repaired tetralogy of Fallot (TOF) is poorly understood. We therefore aimed to examine the relationships between cardiac MRI and cardiopulmonary exercise test variables in adult repaired TOF patients. In particular, we sought to determine the role of RV mass in determining exercise capacity.
View Article and Find Full Text PDFBackground: The mechanisms whereby cardiac output is augmented with exercise in adult repaired tetralogy of Fallot (TOF) are poorly characterised.
Methods: 16 repaired TOF patients (25 ± 7 years of age) and 8 age and sex matched controls (25 ± 4 years of age) underwent cardiopulmonary exercise testing and then real-time cardiac MRI (1.5 T) at rest and whilst exercising within the scanner, aiming for 30% heart rate reserve (Level 1) and 60% heart rate reserve (Level 2), using a custom-built MRI compatible foot pedal device.
Background: The time course of progressive dilatation of the right ventricle (RV) in adults with pulmonary regurgitation (PR) late after repair of tetralogy of Fallot (TOF) is poorly characterized.
Methods: We analysed cardiac MRI data (1.5 T) from 14 adult repaired TOF patients (26 ± 11 years of age) with dilated RVs and known significant PR, on 2 separate visits with a between MRI period of 2.
Background: Pulmonary valve replacement (PVR) is commonly performed late after Tetralogy of Fallot (TOF) repair. We examined the effects of PVR on cardiac structure, function and exercise capacity in adults with repaired TOF.
Methods: Eighteen adult patients with repaired TOF and severe pulmonary regurgitation (PR) with right ventricular (RV) dilatation requiring PVR for clinical reasons (age; 25±8 years) were recruited to undergo cardiac MRI (1.
Background: Despite early repair, patients with aortic coarctation (CoA) continue to have a reduced life expectancy due to the development of late complications. We sought to define the rate of aortic abnormalities in patients with previous CoA repair, referred for surveillance magnetic resonance (MR) imaging.
Methods: We evaluated 59 asymptomatic adults consecutively for repaired CoA with MR imaging between 2008 and 2012.
Article Synopsis
- The study aimed to compare exercise capacity and resting stroke volume in survivors of tetralogy of Fallot (TOF) repair based on their right ventricle end-diastolic volume (RVEDVi), particularly above or below the 150 ml/m² threshold for pulmonary valve replacement (PVR).
- A cross-sectional analysis included 55 patients who underwent cardiovascular MRI and exercise tests, revealing that those with RVEDVi above 150 ml/m² experienced higher pulmonary regurgitation and indexed RV stroke volume, but lower RV ejection fraction.
- Despite these differences, no significant variation in exercise capacity was observed between the two groups, suggesting that the optimal timing for PVR surgery in TOF patients is still not well