Angiogenesis and CD34 expression as a predictor of recurrence in oral squamous cell carcinoma.

Purpose: To assess immunohistologic features of angiogenesis of T1N0M0 oral squamous cell carcinoma (OSCC), and to identify predictors of regional recurrence. The identification of prognostic markers of early lymph node involvement in OSCC could allow for the use of more targeted biologic therapies for patients with early-stage tumors.

Patients And Methods: The study included patients treated for T1N0M0 OSCC at the Mayo Clinic from 1986 to 2001.