Publications by authors named "David J Ozeri"

Background: The impact of the coronavirus disease 2019 (COVID-19) pandemic on patient populations can be divided to direct consequences of the disease and indirect implications of changes imposed on the national healthcare systems. The impact of the later survival of chronic hemodialysis patients is still unknown.

Objectives: To examine the impact of quarantine on health outcomes of dialysis patients.

View Article and Find Full Text PDF

Background: Completing internal medicine specialty training in Israel involves passing the Israel National Internal Medicine Exam (Shlav Aleph), a challenging multiple-choice test. multiple-choice test. Chat generative pre-trained transformer (ChatGPT) 3.

View Article and Find Full Text PDF

Background: Familial Mediterranean Fever (FMF) is a genetic disorder characterized by recurrent episodes of fever and inflammation in various organs, including the joints. Traditionally, the arthritis of FMF has been considered relatively harmless. However, anecdotal evidence has suggested that it may contribute to long-term joint damage, which may necessitate surgical joint replacement.

View Article and Find Full Text PDF

Previous studies have established a relationship between bacterial proteins and autoimmune diseases through several mechanisms. Infective endocarditis is known for its immunological phenomena, and the presence of antineutrophil cytoplasmic antibodies (ANCA) antibodies has been previously demonstrated in several infectious diseases. This retrospective, comparative, and descriptive study examined the relationship between infective endocarditis and the presence of ANCA antibodies.

View Article and Find Full Text PDF

Introduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked enzymatic disorder that is particularly prevalent in Africa, Asia, and the Middle East. This study aimed to assess the long-term health risks associated with G6PD deficiency.

Methods: A retrospective cohort study was conducted using data from a national healthcare provider in Israel (Leumit Health Services).

View Article and Find Full Text PDF
Article Synopsis
  • G6PD deficiency is a genetic disorder affecting enzyme function, especially common in populations from Africa, Asia, and the Middle East, with a notable prevalence of 14% among black men in the US.
  • A study compared health records of 7,473 G6PD deficient individuals with 29,892 controls in Israel, revealing significantly higher rates of autoimmune disorders, infections, and allergies in the G6PD group over an average follow-up of 14.3 years.
  • Results indicated substantial increased risks for specific autoimmune conditions like rheumatoid arthritis and lupus in G6PD deficient individuals, highlighting long-term health risks associated with the deficiency.
View Article and Find Full Text PDF
Article Synopsis
  • The study examines the cardiovascular risk and exercise performance in individuals with asymptomatic diverticulosis compared to those without the condition over a 10-year period.
  • Results show that individuals aged 50-69 with diverticulosis had a higher atherosclerotic cardiovascular disease (ASCVD) score, indicating increased cardiovascular risk.
  • Despite the higher risk, exercise performance was similar between both groups, and certain factors like age, smoking, hypertension, obesity, and male sex were associated with the prevalence of diverticulosis.
View Article and Find Full Text PDF

Background: Conflicting reports exist regarding the racial and the gender distribution of rheumatoid arthritis-related interstitial lung disease (RA-ILD). In a major population study of predominately Whites, RA-ILD was reported mainly among smoker middle-aged men. However, recent data suggest that the disease is that of elderly women.

View Article and Find Full Text PDF

Rheumatoid arthritis (RA) patients have nearly twice the risk of cardiovascular disease (CVD) compared to the general population. We aimed to assess, in a predominantly Black population, the prevalence of traditional and RA-specific CVD risk factors and therapeutic patterns. Utilizing ICD codes, we identified 503 RA patients ≥18 years old who were seen from 2010 to 2017.

View Article and Find Full Text PDF

Anti-neutrophil cytoplasmic antibodies (ANCA) play an important role in the pathogenesis of pauci-immune renal vasculitis. However, in 10% of the cases, ANCA are absent. We present a case of a 64-year-old man with a chronic untreated hepatitis C virus infection and Middle Eastern thalassemia who was ANCA-negative when he was hospitalized due to acute kidney injury and accounts for an uncommon presentation of renal vasculitis.

View Article and Find Full Text PDF

The advent of hydroxyurea and advanced medical care, including immunizations has led to improved survival among patients with Sickle Cell Disease (SCD). This prolonged survival however, introduces a chronic inflammatory disorder, Rheumatoid Arthritis (RA), which presents at a relatively older age and is rarely reported among SCD patients. In this review, we highlight the epidemiological association of SCD-RA and discuss the underlying common pathogenetic mechanisms, such as endothelial dysfunction, the role of inflammatory cytokines and oxidative stress.

View Article and Find Full Text PDF

Objectives: Rheumatoid arthritis (RA) has been rarely reported in association with sickle cell disease (SCD). Our study aimed to estimate the prevalence of RA in SCD population and to describe the clinical characteristics of RA associated with SCD.

Methods: Retrospective chart review of SCD and RA patients followed at 2 large urban hospitals.

View Article and Find Full Text PDF