Publications by authors named "David J Hunter"
Objectives: Explore a newly defined composite measure of symptom progression for knee osteoarthritis (KOA) in a large, randomized study of a potential disease-modifying osteoarthritis drug (DMOAD).
Design: Using longitudinal KOA studies, a potential composite endpoint of time to symptom progression was defined as the first occurrence of worsening of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain of ≥10 points with no improvement (≤9 point decrease) in WOMAC Function (0-100 scale). A post hoc analysis explored discrimination and association with structural outcomes in the sprifermin FORWARD trial through Years 3 and 5.
Introduction: We compared the 12-months effects of arthroscopic surgery and physiotherapist-led care for femoroacetabular impingement (FAI) syndrome on the time-varying magnitude of hip contact force and muscle contributions to hip contact force during walking.
Methods: Secondary analysis was performed on thirty-seven individuals with FAI syndrome who received biomechanical assessment before and 12-months following either arthroscopic surgery (n = 17) or physiotherapist-led care (Personalised Hip Therapy, PHT) (n = 20). At both time points, three-dimensional whole-body motions, ground reaction forces, and surface electromyograms (n = 14) were acquired during overground walking.
Background: The I/D polymorphism has been suggested to be associated with multiple chronic diseases and sports modalities, which has public health implications for global populations and sport performance. This updated review aims to strengthen the association and identify sporting disciplines that are most influenced by the gene polymorphism using a meta-analysis approach.
Methods: Published studies on the association between the I/D polymorphism and elite endurance and power were collected until 15 June 2024.
Objective: The Osteoarthritis Chronic Care Program (OACCP) has been implemented in Australian public hospitals to deliver best evidence osteoarthritis (OA) care. It is important to ensure that the OACCP continues to deliver evidence-based OA care as intended. We aimed to identify barriers and enablers to delivering the OACCP, prioritize the barriers, and generate strategies to address them.
View Article and Find Full Text PDFExpression of Concern; Comparison of weight loss interventions in overweight and obese adults with knee osteoarthritis: a systematic review and network meta-analysis of randomized trials.
Osteoarthritis Cartilage
November 2024
Article Synopsis
- The study aimed to see if changes in MRI-defined bone marrow lesions (BMLs) and inflammatory markers are linked to cartilage loss in knees with osteoarthritis over 24 months.
- It analyzed data from 629 participants, finding that knees with no BMLs showed significantly less cartilage loss, while those with increasing BML size experienced more cartilage loss.
- The results suggest that preventing the growth of BMLs and worsening of Hoffa-synovitis could help reduce cartilage deterioration in osteoarthritis patients.
Objective: The study objective was to determine whether the clinical response of older adults with knee osteoarthritis and overweight or obesity to 18 months of diet and exercise (D + E) or attention control (C) interventions differed between participants from rural versus urban communities.
Methods: Participants were 823 older adults (mean age, 64.6 years; 77% women) with knee osteoarthritis and overweight or obesity who resided in rural (n = 410) and urban (n = 413) counties in North Carolina.
Article Synopsis
- This study evaluates when exercise is most effective in treating osteoarthritis (OA) symptoms and how different types of exercise impact these symptoms.
- It uses data from various databases to analyze randomized controlled trials that focus on the effects of exercise on knee, hip, or hand OA.
- Results show that exercise effectiveness peaks between 1.6 to 7.2 weeks after starting, with local exercise techniques proving to be the most beneficial in reducing pain and improving function.
Article Synopsis
- The study aims to evaluate the effectiveness and safety of a specific oral complementary medicine formulation compared to a placebo for reducing pain in individuals with knee osteoarthritis over 12 weeks.
- A total of 82 participants aged 40 and older will be randomly assigned to receive either the complementary medicine or a placebo, with key measurements focused on changes in knee pain intensity and related health outcomes.
- The research follows ethical guidelines and intends to share findings through various channels, potentially influencing future standards for managing knee osteoarthritis with complementary medicines.
Article Synopsis
- Bone marrow lesions (BMLs) are linked to an increased risk of developing knee osteoarthritis (OA), and deep learning (DL) can help in measuring BML volumes from MRI scans.
- This study used a DL model to analyze MRI scans from a cohort of participants, categorizing their knees based on changes in BML volume over four years to assess the risk of developing knee OA.
- Results indicated that knees with increasing BML volumes were significantly more likely to develop both radiographic and symptomatic OA compared to knees that remained BML-free or showed BML regression.
Article Synopsis
- Ankle osteoarthritis (OA) lacks specific management guidelines, and studies typically focus on education, weight loss, and exercise for OA across different body regions.
- The objective of the study was to assess the feasibility of a randomized controlled trial (RCT) comparing physiotherapist-led education and exercise to general advice for ankle OA management.
- Results showed high feasibility, with a 97% consent rate, 71% adherence to interventions, 94% intervention fidelity, and 87% completion of follow-up measures, indicating potential for a larger RCT in the future.
Comparison of weight loss interventions in overweight and obese adults with knee osteoarthritis: A systematic review and network meta-analysis of randomized trials.
Osteoarthritis Cartilage
September 2024
Article Synopsis
- The objective of the study was to evaluate different weight-loss strategies for improving symptoms in overweight or obese individuals with osteoarthritis (OA), specifically knee OA (KOA).
- Researchers conducted a comprehensive search for studies and performed network meta-analyses to compare the effectiveness of seven different interventions, including diet, exercise, and psychological support.
- Results showed that interventions combining psychological strategies with diet and exercise (PDE) were the most effective for weight loss, while all interventions significantly reduced weight compared to controls; however, only the diet and exercise combo (DE) demonstrated notable pain relief.
Article Synopsis
- - Rheumatoid arthritis (RA) is an autoimmune disease that affects joint movement and has a strong genetic component, with many genes linked to its risk identified through genome-wide association studies (GWAS).
- - The study aimed to evaluate specific genetic polymorphisms related to RA and create a polygenic risk score (PRS) to assess genetic contributions to the disease.
- - Results showed significant associations with RA risk from specific genetic markers, and the PRS was notably higher in RA patients compared to controls, indicating its potential use in personalized medicine and prevention strategies.
Article Synopsis
- Osteoarthritis is a common condition, but the link between specific serum biomarkers like calcium, vitamin D, and C-reactive protein (CRP) and mortality in these patients is not well understood.
- This study analyzed data from over 500,000 individuals, focusing on 49,082 with osteoarthritis, to assess the impact of these biomarkers on mortality over 15 years.
- High serum calcium, low serum calcium, vitamin D insufficiency, and high CRP levels were all significantly related to increased all-cause mortality and cardiovascular deaths among the osteoarthritis population.
Article Synopsis
- Osteoarthritis is a major disability cause, and exploring antidiabetic medications as disease-modifying osteoarthritis drugs (DMOADs) could significantly improve treatment options.
- A comprehensive analysis involving genetic methodologies identified 14 potential drug targets among clinical antidiabetic medications, revealing different relationships between these drugs and osteoarthritis risk.
- Notably, certain medications, like sulfonylureas, increased osteoarthritis risk, while thiazolidinediones and others were linked to reduced risk in specific joints, hinting at promising new therapeutic approaches.
Article Synopsis
- - Coronary artery disease (CAD) is a major health issue in India, and this study looked at ten genetic polymorphisms affecting oxidative stress, blood pressure, and lipid metabolism in the Jat Sikh population to understand their link to CAD risk.
- - The research found that seven of these polymorphisms, specifically M235T, T174M, and A1166C, showed significant associations with increased CAD risk, with some haplotypes linked to higher risk even when accounting for other factors.
- - A higher polygenic risk score indicated a nearly double risk of developing CAD, highlighting important genetic factors for potential clinical and public health strategies in preventing and managing coronary artery disease.
Objectives: The recent Flare-OA questionnaire measuring flare in knee and hip osteoarthritis (OA) (19 items in 5 domains, numerical rating scale) showed good psychometric properties along with classical test theory. This study aimed to determine its scaling properties by Rasch analysis and to present evidence for a refined scalable version.
Study Design And Setting: The participants were 398 subjects (mean age 64 years [standard deviation = 8.