Publications by authors named "David J Escobar"

Entrustable professional activities (EPAs) have been implemented in various medical specialties, and the Pathology National EPA Working Group has piloted the implementation of four pathology EPAs. We recently published the development of EPAs within our surgical pathology rotation. Following a six-month pilot, a survey demonstrated that faculty and residents found the forms helpful and easy to use and easy to understand, and EPAs have been fully incorporated into our surgical pathology rotation.

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Context.—: Many drugs can induce liver injury; however, vaccine-induced liver injury is a rare phenomenon. SARS-CoV-2 messenger RNA (mRNA) vaccines are now widely administered, and clinical evidence of liver injury has been reported.

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Recurrence within one or two years is common after Crohn's disease (CD) resection. In this study, we seek to identify histologic features in CD resections that may predict earlier (≤18 months) recurrence to potentially guide post-operative management. A single-institution, retrospective review was performed on patients with first-time CD bowel resection specimens (2002-2007).

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  • Diagnosing biliary system conditions is challenging due to anatomic variations and the dynamic nature of the biliary tract, which can complicate identification of normal versus abnormal findings.
  • Choledochal cysts are important to diagnose due to their potential risk for developing into cholangiocarcinoma; while choledocholithiasis (bile duct stones) is the most common cause of biliary dilation, MRI is the most sensitive imaging method for detection.
  • Understanding different types of biliary malignancies, including intraductal papillary biliary neoplasms and cholangiocarcinoma, is essential for correct staging and treatment options, as well as differentiating between various inflammatory conditions affecting the biliary tree.
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  • Pancreatic cystic neoplasms are diverse lesions with varying biological behaviors, ranging from benign types like serous cystic neoplasms (SCAs) to potentially malignant ones like intraductal papillary mucinous neoplasms.
  • SCAs can appear in different forms on imaging, including microcystic, honeycomb, and solid patterns, and may be found solitary or multiple, particularly in cases like von Hippel-Lindau disease.
  • Advanced imaging techniques, including endoscopic ultrasonography and immunohistochemistry, enhance the diagnostic accuracy and differentiation of SCAs from other pancreatic cystic lesions.
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  • * In a case series of HER2 positive esophageal adenocarcinoma LM, one patient showed a positive long-term response to intrathecal trastuzumab, while another experienced rapid disease progression.
  • * Intrathecal trastuzumab is considered a promising and well-tolerated treatment option for HER2 positive esophageal carcinoma LM, warranting further investigation despite mixed patient outcomes.
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Eosinophilic gastrointestinal (GI) disorders are a group of conditions marked by pathologic eosinophilic infiltration of one or multiple locations in the GI tract. Conditions include eosinophilic esophagitis, eosinophilic gastritis, eosinophilic enteritis, and eosinophilic colitis. The site and depth of eosinophilic infiltration of the GI tract usually determines clinical presentation.

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Background: Crohn's disease (CD) is a condition on the spectrum of inflammatory bowel disease that affects up to 20 people per 100,000 in the US annually, and with incidence increasing. One of the most significant sources of morbidity in CD is the formation of strictures, with resultant intestinal blockage a common indication for hospitalization and surgical intervention in these patients. The pathophysiology of stricture formation is not fully understood.

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The cadherin-catenin adhesion complex is a key contributor to epithelial tissue stability and dynamic cell movements during development and tissue renewal. How this complex is regulated to accomplish these functions is not fully understood. We identified several phosphorylation sites in mammalian αE-catenin (also known as catenin α-1) and Drosophila α-Catenin within a flexible linker located between the middle (M)-region and the carboxy-terminal actin-binding domain.

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Planarians grow and regenerate organs by coordinating proliferation and differentiation of pluripotent stem cells with remodeling of postmitotic tissues. Understanding how these processes are orchestrated requires characterizing cell-type-specific gene expression programs and their regulation during regeneration and homeostasis. To this end, we analyzed the expression profile of planarian intestinal phagocytes, cells responsible for digestion and nutrient storage/distribution.

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