Publications by authors named "David J E Henshaw"
Med Hypotheses
November 2020
Article Synopsis
- SARS-CoV-2 and SARS-CoV-1 share a lineage but exhibit differences in disease presentation, with COVID-19 often causing severe multi-organ issues, particularly in elderly patients or those with underlying health conditions.
- The disease is linked to dysfunction of the renin-angiotensin system (RAS), primarily due to reduced ACE2 function, which is crucial for viral entry and regulating vascular health.
- This dysfunction leads to complications like inflammation, thrombosis, and tissue damage, as well as a loss of protective angiotensin (1-7), exacerbating the disease's severity and multi-system impact.
