Eruptive postoperative squamous cell carcinomas exhibiting a pathergy-like reaction around surgical wound sites.

Background: The isomorphic response of Koebner and the pathergy skin reaction have not classically been associated with neoplastic processes such as cutaneous squamous cell carcinoma (SCC).

Objective: We report 5 patients who developed postoperative eruptive SCCs within and around the healed or healing sites of excised nonmelanoma skin cancers. The original cancers were all excised with histologically tumor-free margins and the subsequent eruptive SCCs were sometimes multiple.