Publications by authors named "David I Wang"
Efficient loading of drugs in novel delivery agents has the potential to substantially improve therapy by targeting the diseased tissue while avoiding unwanted side effects. Here we report the first systematic study of the loading mechanism of phenanthriplatin and its analogs into tobacco mosaic virus (TMV), previously used by our group as an efficient carrier for anticancer drug delivery. A detailed investigation of the preferential uptake of phenanthriplatin in its aquated form (∼2000 molecules per TMV particle versus ∼1000 for the chlorido form) is provided.
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- * Researchers explored the anticancer potential of osmium(VI) nitrido compounds on GBM initiating cells, finding that they show significant effectiveness in both lab and animal studies.
- * The study demonstrated that osmium compounds induce rapid cell death at low concentrations and lead to increased survival rates in animal models, suggesting a promising new avenue for GBM treatment.