Publications by authors named "David Hyunjung Chung"
Article Synopsis
- Highly pathogenic avian influenza (HPAI) H5 viruses have rapidly spread worldwide and are evolving into different strains, necessitating more effective vaccines.
- A new chimeric virus-like particle (VLP) vaccine combines hemagglutinins from two different HPAI H5 clades, providing broader antibody responses in immunized chickens and ducks compared to single-strain vaccines.
- Despite the chimeric VLP showing effectiveness in chickens, ducks generated lower antibody levels, indicating challenges in vaccination efficacy for ducks and highlighting the need for improved vaccination strategies for them.
Article Synopsis
- Current influenza vaccines work well for younger people but are less effective for the elderly due to age-related immune decline (immunosenescence).
- Research on GPI-anchored cytokine-adjuvants combined with influenza hemagglutinin virus-like particles (HA-VLP) showed improved immune responses and reduced viral replication in aged mice compared to standard HA-VLP vaccines.
- The study concludes that using cytokine-adjuvanted HA-VLP vaccines could potentially improve protection against influenza A virus for older adults, even without the presence of neutralizing antibodies.
Wild aquatic birds are the natural reservoirs of avian influenza viruses (AIVs). It is estimated that 100 million seabirds live in the Antarctic Peninsula and adjacent islands, regularly encountering migratory birds that use the islands to nest. Between 2010 and 2013, we collected samples from 865 seabirds in Elephant, King George and Livingston islands, around Antarctica Peninsula: chinstrap penguin (n = 143); gentoo penguin (n = 208); Adelie penguin (n = 46); brown skua (n = 90); Cape petrel (n = 115) and southern giant petrel (n = 263).
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