Financial analysis of revision hip surgery at a tertiary referral centre as classified using the British Hip Society Revision Hip Complexity Classification.

Aims: The burden of revision total hip arthroplasty (rTHA) continues to grow. The surgery is complex and associated with significant costs. Regional rTHA networks have been proposed to improve outcomes and to reduce re-revisions, and therefore costs.

Atypical Polycystic Kidney Disease as defined by Imaging.

Using age- and height-adjusted total kidney volume, the Mayo Clinic Imaging Classification provides a validated approach to assess the risk of chronic kidney disease (CKD) progression in autosomal dominant polycystic kidney disease (ADPKD), but requires excluding patients with atypical imaging patterns, whose clinical characteristics have been poorly defined. We report an analysis of the prevalence, clinical and genetic characteristics of patients with atypical polycystic kidney disease by imaging. Patients from the extended Toronto Genetic Epidemiology Study of Polycystic Kidney Disease recruited between 2016 and 2018 completed a standardized clinical questionnaire, kidney function assessment, genetic testing, and kidney imaging by magnetic resonance or computed tomography.

A Framework to Ensure Patient Partners Have Equal and Contributing Voices Throughout the Research Program Evaluation Process.

Purpose Of Program: Traditionally, peer review was a closed process conducted only by individuals working in the research field. To establish a more integrated and patient-centered approach, one of Canada's largest kidney research networks (Can-SOLVE CKD) has created a Research Operations Committee (ROC) that includes patients as key members. The ROC represents one way for achieving meaningful patient-oriented research (POR).

Prognostic Performance of Kidney Volume Measurement for Polycystic Kidney Disease: A Comparative Study of Ellipsoid vs. Manual Segmentation.

Total kidney volume (TKV) is a validated prognostic biomarker for risk assessment in autosomal dominant polycystic kidney disease (ADPKD). TKV by manual segmentation (MS) is the "gold standard" but is time-consuming and requires expertise. The purpose of this study was to compare TKV-based prognostic performance by ellipsoid (EL) vs.

A modified spectrogram with possible application as a visual hearing aid for the deaf.

A modified spectrogram was developed, substantially improving visual word recognition over that of traditional spectrograms from 23% to 80%. Traditional spectrograms are difficult to interpret quickly due partly to poor contrast, subtle cues, and extraneous detail. Improvements developed here include increased frequency resolution, enhancement of inconspicuous but relevant information, and elimination of extraneous detail.

A randomized controlled trial comparing in-person and wiki-inspired nominal group techniques for engaging stakeholders in chronic kidney disease research prioritization.

Background: Few studies have evaluated stakeholder engagement in chronic kidney disease (CKD) research prioritization. In this two-arm, parallel group randomized controlled trial, we sought to compare an in-person nominal group technique (NGT) approach with an online wiki-inspired alternative to determining the top 10 CKD research priorities, and to evaluate stakeholder engagement and satisfaction with each process.

Methods: Eligible participants included adults ≥18 years with access to a computer and Internet, high health literacy, and from one of the following stakeholder groups: patients with CKD not on dialysis, their caregivers, health care providers who care for patients with CKD, or CKD-related health policymakers.

Comparative study on the temporal contrast of femtosecond mode-locked laser oscillators.

We have investigated the temporal intensity contrast characteristics from a broad range of mode-locked short-pulse oscillators used for seeding high-power terawatt and petawatt-class laser systems. Saturable absorber (SESAM), Kerr lens (KLM), nonlinear polarization evolution (NPE) in optical fibers and synchronously pumped optical parametric oscillator (OPO) mode-locked sources have been measured using a third-order autocorrelator with up to 10 dynamic range. We restricted the temporal characterization to features <30  ps about the laser pulse that reflect fundamental mode-locking processes.

Determining the research priorities for patients with chronic kidney disease not on dialysis.

Background: The importance of engaging key stakeholders, and patients in particular, in determining research priorities has been recognized. We sought to identify the top 10 research priorities for patients with non-dialysis chronic kidney disease (CKD), their caregivers, and the clinicians and policy-makers involved in their care.

Methods: We used the four-step James Lind Alliance process to establish the top 10 research priorities.

Multivalent nanoparticle networks enable point-of-care detection of human phospholipase-A2 in serum.

A rapid and highly sensitive point-of-care (PoC) lateral flow assay for phospholipase A2 (PLA2) is demonstrated in serum through the enzyme-triggered release of a new class of biotinylated multiarmed polymers from a liposome substrate. Signal from the enzyme activity is generated by the adhesion of polystreptavidin-coated gold nanoparticle networks to the lateral flow device, which leads to the appearance of a red test line due to the localized surface plasmon resonance effect of the gold. The use of a liposome as the enzyme substrate and multivalent linkers to link the nanoparticles leads to amplification of the signal, as the cleavage of a small amount of lipids is able to release a large amount of polymer linker and adhesion of an even larger amount of gold nanoparticles.

Contrast enhancements to petawatt lasers using short pulse optical parametric amplifiers and frequency doubling.

This paper describes the integration of a short pulse optical parametric amplifier into the chirped pulse amplification beam lines of the Orion laser facility. This enables Orion to generate petawatt laser pulses at 1054 nm with a nanosecond contrast of >10(10). By combining this with frequency-doubling post compression, we can generate 100 J, 500 fs laser pulses with a nanosecond contrast calculated to be ∼10(18).

The first report of survival post Rothia aeria endocarditis.

A 61-year-old patient presented with drowsiness, decreased appetite and weight loss. On examination he had several splinter haemorrhages and a tender mass over the right temporal region. Respiratory and abdominal examinations were unremarkable and heart sounds were normal with no clinically audible murmurs.

Ultrahigh contrast from a frequency-doubled chirped-pulse-amplification beamline.

This paper describes frequency-doubled operation of a high-energy chirped-pulse-amplification beamline. Efficient type-I second-harmonic generation was achieved using a 3 mm thick 320 mm aperture KDP crystal. Shots were fired at a range of energies achieving more than 100 J in a subpicosecond, 527 nm laser pulse with a power contrast of 10(14).

Overview of laser systems for the Orion facility at the AWE.

The commissioning of the Orion laser facility at the Atomic Weapons Establishment (AWE) in the UK has recently been completed. The facility is a twelve beam Nd:glass-based system for studying high energy density physics. It consists of ten frequency-tripled beam-lines operating with nanosecond pulses, synchronized with two beam-lines with subpicosecond pulses, each capable of delivering 500 J to target.

Pulse generation and preamplification for long pulse beamlines of Orion laser facility.

We describe the pulse generation, shaping, and preamplification system for the nanosecond beamlines of the Orion laser facility. The system generates shaped laser pulses of up to approximately 1 J of 100 ps-5 ns duration with a programmable temporal profile. The laser has a 30th-power supergaussian spatial profile and is diffraction limited.

Spontaneous intracranial hypotension from intradural thoracic disc herniation. Case report.

Spontaneous intracranial hypotension (SIH) may result from occult leaks anywhere along the neuraxis. Although this syndrome has been recognized over the past 10 years in the neurology and radiology literature, the typical magnetic resonance (MR) imaging picture and clinical course are less well known to neurosurgeons. The authors describe the case of a patient with positional headache and MR imaging findings typical of SIH that resulted from an intradural disc herniation.

Gerontological perspectives on crime and nuisance: the elderly critically evaluate housing designs in the British city.

This paper investigates the perceptions of the elderly in relation to crime and nuisance and the fear of crime associated with stereotypical British housing designs. Demographically, this diverse though highly urbanized group continues to grow; group members' observations, therefore, have increasing social relevance and political importance and are crucial for assessing and informing both current policy and the evolution of future policy initiatives. Crime Prevention Through Environmental Design (CPTED) has become popular once again in America, Australia, Canada, South Africa, as well as in Europe and Britain.