Virtual screening and zebrafish models in tandem, for drug discovery and development.

Introduction: The combination of Virtual Screening (VS) techniques with in screening in the zebrafish model is currently being used in tandem for drug development in a faster and more efficient way.

Areas Covered: We review the different virtual screening techniques, the use of zebrafish as a vertebrate model for drug discovery and the synergy that exists between them.

Expert Opinion: We highlight the advantages of combining virtual and zebrafish larvae screening for drug discovery.

Senescence-Independent Anti-Inflammatory Activity of the Senolytic Drugs Dasatinib, Navitoclax, and Venetoclax in Zebrafish Models of Chronic Inflammation.

Telomere shortening is the main molecular mechanism of aging, but not the only one. The adaptive immune system also ages, and older organisms tend to develop a chronic pro-inflammatory status with low-grade inflammation characterized by chronic activation of the innate immune system, called inflammaging. One of the main stimuli that fuels inflammaging is a high nutrient intake, triggering a metabolic inflammation process called metainflammation.