Publications by authors named "David Hernan Aguirre-Padilla"
Article Synopsis
- Deep brain stimulation (DBS) is commonly used to alleviate symptoms of movement disorders like Parkinson's disease (PD), but its effects on the accumulation of harmful proteins in neurodegeneration are not fully understood.
- This study investigated how high-frequency electrical stimulation affects levels and clustering of the protein alpha-synuclein (α-Syn), which is linked to the loss of brain cells in PD.
- The findings revealed that high-frequency stimulation reduced both mutant α-Syn levels and its harmful clumping in neurons, suggesting that DBS may not only treat symptoms but could also modify the disease by targeting pathological proteins.
Background: Rechargeable implantable pulse generators (r-IPGs) for deep brain stimulation (DBS) promise longer battery life and fewer replacement surgeries versus non-rechargeable systems. Long-term data on the effects of recharging in patients who received DBS for psychiatric indications is limited. The Recharge PSYCH trial is the first study that included DBS patients with psychiatric disorders treated with different r-IPG models.
View Article and Find Full Text PDFThe authors report on a female patient with left-dominant Parkinson's disease with motor fluctuations and levodopa-induced dyskinesias and comorbid postherpetic neuralgia (PHN), who underwent a right-sided pallidotomy. Besides a substantial improvement in her Parkinson's symptoms, she reported an immediate and complete disappearance of PHN. This neuralgia had been long-standing, pharmacologically refractory, and severe (preoperative Brief Pain Inventory [BPI] pain severity score of 8.
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