A Novel Weaning Protocol for High-Flow Nasal Cannula in the PICU.

Objective: High-flow nasal cannula use in the PICU continues to increase; however, a protocol for weaning patients has yet to be published. This study aimed to create an efficient and safe protocol for weaning high-flow nasal cannula.

Design: A Respiratory Assessment Score was created using two validated scoring systems.

Isoflurane for life-threatening bronchospasm: a 15-year single-center experience.

Background: Children with severe bronchospasm requiring mechanical ventilation may become refractory to conventional therapy. In these critically ill patients, isoflurane is an inhaled anesthetic agent available in some centers to treat bronchospasm. We hypothesized that isoflurane is safe and would lead to improved gas exchange in children with life-threatening bronchospasm refractory to conventional therapy.

Automated measurement of the lower inflection point in a pediatric lung model.

Objective: To determine which flow setting most accurately detects the lower inflection point (Pflex) using an automated constant flow method and varying endotracheal tube (ETT) sizes with and without an airleak in a pediatric lung model.

Design: Interventional laboratory study.

Setting: Children's hospital research center.

Gas exchange and lung mechanics during high frequency ventilation in the perflubron-treated lung.

Objective: To identify the effect of perflubron on gas exchange and lung mechanics during high frequency oscillatory ventilation in an animal model.

Design: Prospective randomized animal trial.

Subjects: Eighteen Yorkshire swine.