Publications by authors named "David H Ostrodci"
Inflammation
December 2013
Article Synopsis
- Inflammation is crucial in the development of atherosclerosis and coronary artery disease (CAD), with Interleukin-2 (IL-2) being a key proinflammatory cytokine that promotes T cell growth.
- The study investigated the relationship between IL-2 genetic variations (specifically -330T/G and +114T/G polymorphisms) and CAD by comparing 692 CAD patients with 723 healthy individuals.
- Results indicated that the IL-2 -330GG genotype was more common among CAD patients, who also had higher serum IL-2 levels than controls, suggesting that IL-2 may increase susceptibility to CAD and correlate with its severity.
