Recent Findings on Therapeutic Cancer Vaccines: An Updated Review.

Cancer remains one of the global leading causes of death and various vaccines have been developed over the years against it, including cell-based, nucleic acid-based, and viral-based cancer vaccines. Although many vaccines have been effective in in vivo and clinical studies and some have been FDA-approved, there are major limitations to overcome: (1) developing one universal vaccine for a specific cancer is difficult, as tumors with different antigens are different for different individuals, (2) the tumor antigens may be similar to the body's own antigens, and (3) there is the possibility of cancer recurrence. Therefore, developing personalized cancer vaccines with the ability to distinguish between the tumor and the body's antigens is indispensable.

The Relationship Between Molecular Symmetry and Physicochemical Properties Involving Boiling and Melting of Organic Compounds.

Objective And Methods: The reliable estimation of phase transition physicochemical properties such as boiling and melting points can be valuable when designing compounds with desired physicochemical properties. This study explores the role of external rotational symmetry in determining boiling and melting points of select organic compounds. Using experimental data from the literature, the entropies of boiling and fusion were obtained for 541 compounds.

Investigating material basis and molecular mechanism of Qing Cuo formula in the treatment of acne based on animal experiments, UPLC-LTQ-Orbitrap-MS and network pharmacology.

Context: Qing Cuo Formula (QCF) is a traditional Chinese medicine for treating acne, but its active compounds and molecular mechanisms are unclear.

Objective: To investigate the material basis and molecular mechanism of QCF.

Materials And Methods: experiments were conducted on 60 male golden hamsters with damp-heat acne, with a blank group, a spironolactone group and 3 QCF administration groups (given high, medium and low doses) over a 30-day period.

Effects of the Interface between Inorganic and Organic Components in a BiTe-Polypyrrole Bulk Composite on Its Thermoelectric Performance.

We provided a method to hybridize BiTe with polypyrrole, thus forming an inorganic/organic bulk composite (BiTe-polypyrrole), in which the effects of energy band junction and phonon scattering were expected to occur at the interface of the two components. BiTe-polypyrrole exhibited a considerably high Seebeck coefficient compared to pristine BiTe, and thus it recorded a somewhat increased power factor despite the loss in electrical conductivity caused by the organic component, polypyrrole. BiTe-polypyrrole also exhibited much lower thermal conductivity than pristine BiTe because of the phonon scattering effect at the interface.

An Aerosol Climatology and Implications for Clouds at a Remote Marine Site: Case Study Over Bermuda.

Aerosol characteristics and aerosol-cloud interactions remain uncertain in remote marine regions. We use over a decade of data (2000-2012) from the NASA AErosol RObotic NETwork, aerosol and wet deposition samples, satellite remote sensors, and models to examine aerosol and cloud droplet number characteristics at a representative open ocean site (Bermuda) over the Western North Atlantic Ocean (WNAO). Annual mean values were as follows: aerosol optical depth (AOD) = 0.

The relationship of CCL4, BCL2A1, and NFKBIA genes with premature aging in women of Yin deficiency constitution.

Background: Traditional Chinese Medicine (TCM) defined constitution as a health statue or physical fitness that determines individual susceptibility to diseases. Yin deficiency constitution (YinDC) is a type of constitution closely related to aging. Previous studies found that the characteristic genes of YinDC are part of the inflammatory aging signaling pathways (e.

Sources, frequency, and chemical nature of dust events impacting the United States East Coast.

This study examines 14 years (2004-2017) of surface aerosol composition data from the EPA IMPROVE network with a focus on the monthly profile, sources, and chemical nature of extreme dust events (>92nd percentile of fine soil concentration each month) impacting ten sites along the United States East Coast ranging in latitude from Florida to Maine. Based on trajectory, remote sensing, and reanalysis data, dust events were categorized into four source categories: African, Asian, Mix (African + Asian), and Other (anything other than African and Asian). The results reveal that extreme dust events account for between 3.

Frequency and Character of Extreme Aerosol Events in the Southwestern United States: A Case Study Analysis in Arizona.

This study uses more than a decade's worth of data across Arizona to characterize the spatiotemporal distribution, frequency, and source of extreme aerosol events, defined as when the concentration of a species on a particular day exceeds that of the average plus two standard deviations for that given month. Depending on which of eight sites studied, between 5% and 7% of the total days exhibited an extreme aerosol event due to either extreme levels of PM, PM, and/or fine soil. Grand Canyon exhibited the most extreme event days (120, , 7% of its total days).