Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia.

Purpose: Systems biology approaches can identify critical targets in complex cancer signaling networks to inform new therapy combinations that may overcome conventional treatment resistance.

Experimental Design: We performed integrated analysis of 1,046 childhood B-ALL cases and developed a data-driven network controllability-based approach to identify synergistic key regulator targets in Philadelphia chromosome-like B-acute lymphoblastic leukemia (Ph-like B-ALL), a common high-risk leukemia subtype associated with hyperactive signal transduction and chemoresistance.

Results: We identified 14 dysregulated network nodes in Ph-like ALL involved in aberrant JAK/STAT, Ras/MAPK, and apoptosis pathways and other critical processes.

'Iron lung': distinctive bronchoscopic features of acute iron tablet aspiration.

Three confirmed cases of acute iron tablet-induced necrosis due to a fulminant chemical burn injury to the tracheobronchial tree as a result of accidental inhalation and/or aspiration of iron tablets are described. Although histological confirmation has been relied upon for diagnosis, the distinctive bronchoscopic features may allow prompt recognition and treatment by bronchoscopists to prevent this potentially fatal condition.

EXAMINATION OF POPULATION STRUCTURE IN RED-COCKADED WOODPECKERS USING DNA PROFILES.

The degree to which DNA similarity is related to kinship and population structure in natural populations was investigated for a small population of cooperatively-breeding Red-cockaded Woodpeckers (Picoides borealis) in the western Piedmont region of South Carolina. An independent pedigree was established from records of color-banded individuals. Results of DNA profiles were then examined relative to this pedigree.