Efficacy of topical cobalt chelate CTC-96 against adenovirus in a cell culture model and against adenovirus keratoconjunctivitis in a rabbit model.

Background: Adenovirus (Ad), associated with significant morbidity, has no topical treatment. A leading CTC compound (CTC-96), a Co(III) chelate, was found to have potent in vitro and in vivo antiviral efficacy against herpes viruses. In this study CTC-96 is being tested for possible anti-Adenovirus activity.

RNA-mediated response to heat shock in mammalian cells.

The heat-shock transcription factor 1 (HSF1) has an important role in the heat-shock response in vertebrates by inducing the expression of heat-shock proteins (HSPs) and other cytoprotective proteins. HSF1 is present in unstressed cells in an inactive monomeric form and becomes activated by heat and other stress stimuli. HSF1 activation involves trimerization and acquisition of a site-specific DNA-binding activity, which is negatively regulated by interaction with certain HSPs.

Novel regulatory factors of HSF-1 activation: facts and perspectives regarding their involvement in the age-associated attenuation of the heat shock response.

An attenuated response to stress is characteristic of senescence. Heat shock (HS), a significant form of stress, is delayed and reduced in aging organisms. In the response to heat shock, heat shock factor 1 (HSF-1) is activated by trimerization of its monomeric subunits.

Caenorhabditis elegans--a paradigm for aging research: advantages and limitations.

In 1967, as we became interested in the biology of aging, we were faced with the following basic biological paradox: organisms are endowed with the capacity to detect and repair damage encountered at the molecular and cellular levels and yet functional capacity declines with time. In accordance with Strehler's suggestion (Time, Cells, and Aging, 2nd ed., Academic Press, New York, 1962), we adopted the basic premise that the underlying mechanisms of aging are common to all multi-cellular organisms.