Dopamine: approaches to its side chain labeling with tritium.

Methods are presented to tritiate the side chain of dopamine.

Tritium labelling of several potent fluorinated antipsychotic drugs at high specific activity.

Methods are presented to synthesize and characterize [methylene-3H] haloperidol 2 and [N-methyl-3H]trifluoperazine 6.

Tritiation of imipramine and pseudo irreversible analogues 3-cyanoimipramine and 2-nitroimipramine at high specific activity.

Methods are presented to synthesize and characterize [N-methyl-3H] imipramine 3, [N-methyl-3H] 3-cyanoimipramine 6 and [N-methyl-3H] 2-nitroimipramine 9.

Mu opiate active substances trefentanil and naloxonazine: tritiation at high specific activity.

Methods are presented to synthesize and characterize [propyl-(3)H] trefentanil 3 and [propenyl-(3)H] naloxonazine 6.

The synthesis and characterization of [2,3-3H] gamma-aminobutyric acid via 4-aminotetrolic acid at high specific activity.

Gamma-aminobutyric acid was labelled with tritium by the tritium gas catalytic reduction of a convenient 4-aminotetrolic acid derivative. The purified product was characterized by HPLC and tritium NMR.