Publications by authors named "David Francis Burke"
The genetic basis of antigenic drift of human A/H3N2 influenza virus is crucial to understanding the constraints of influenza evolution and determinants of vaccine escape. Amino acid changes at only seven positions near the receptor binding site of the surface hemagglutinin protein have been shown to be responsible for the major antigenic changes for over forty years. Experimental structures of HA are now available for the majority of the observed antigenic clusters of A/H3N2.
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- Highly pathogenic avian influenza (HPAI) A(H5N1) viruses significantly impact the global poultry industry and pose a risk for pandemics, prompting vaccination efforts in countries like Vietnam since 2005.
- Researchers developed a set of chicken and ferret antisera to analyze how well current vaccines match the circulating viral variants by using hemagglutination inhibition (HI) assays.
- Findings showed distinct antigenic patterns that relate existing poultry vaccines to the effectiveness of in vivo protection, leading to recommendations for more studies on the impacts of genetic changes in viruses on vaccine performance.