Publications by authors named "David Delgado Gestoso"
Article Synopsis
- Macrophages are crucial immune cells that help maintain tissue health, defend against pathogens, and their function can be influenced by their metabolism.
- The study uses various advanced imaging and biochemical techniques to explore how growth hormone (GH) affects the metabolism of inflamed macrophages.
- Results show that GH reprograms these inflammatory macrophages by reducing their metabolism and enhancing mitochondrial function, indicating that targeting macrophage metabolism could be a new strategy for treating inflammatory diseases.
During cell cycle progression in metazoans, the kinetochore is assembled at mitotic onset and disassembled during mitotic exit. Once assembled, the kinetochore complex attached to centromeres interacts directly with the spindle microtubules, the vehicle of chromosome segregation. This reassembly program is assumed to be absent in budding and fission yeast, because most kinetochore proteins are stably maintained at the centromeres throughout the entire cell cycle.
View Article and Find Full Text PDF