Publications by authors named "David Deitchman"
Background: Few antihypertensive therapies have been systematically studied in children and dosages for many agents are either extrapolated from adult studies or obtained from small homogenous pediatric populations. It is well established that adult patients of different races show disparate response to angiotensin-converting enzyme (ACE) inhibitors, however no such studies have been performed in children.
Methods: Two hundred fifty three children ages 6-16 with hypertension or with high normal blood pressure with an associated medical condition requiring antihypertensive therapy were enrolled at 78 clinical sites in the US, Russia, and Israel in a double blind study to evaluate the efficacy of fosinopril compared to placebo.
Article Synopsis
- The study assessed the effectiveness, safety, and dosage of fosinopril in children aged 6 to 16 with hypertension, utilizing a double-blind, placebo-controlled design across 78 clinical sites.
- The trial involved four phases: screening, dose-response, placebo withdrawal, and an open-label safety phase, finding that all tested doses effectively lowered systolic blood pressure in participants.
- Results showed a significant difference in blood pressure increase during the placebo withdrawal, indicating fosinopril's effectiveness, while it was generally well tolerated with few serious side effects, suggesting that starting doses for children should be lower than those for adults.