Publications by authors named "David D McKemy"
Article Synopsis
- - **Genetic Basis of Migraine**: Migraine is largely polygenic, with many genetic variants identified through genome-wide association studies. Key mutations are linked to the TRPM8 channel, which senses cold but may have different activation mechanisms related to migraine.
- - **Role of Artemin and GFRα3**: The study explores how the neurotrophic factor artemin and its receptor GFRα3 influence migraine-related pain through their effects on TRPM8, potentially affecting cold sensitivity and pain responses in migraine models.
- - **Preclinical Findings**: Experiments on mice show that GFRα3 is crucial for mechanical sensitivity in migraine, as blocking artemin reduces migraine-like symptoms, highlighting its significance in
Article Synopsis
- Migraine is influenced by genetics, with most cases being polygenic, which means they are linked to multiple genetic variants, particularly involving the TRPM8 channel, important for sensing cold.
- The study explores the role of the neurotrophic factor artemin and its receptor GFRα3 in migraine pain using rodent models, looking at how various treatments affect pain sensitivity.
- Results highlight the connection between GFRα3 and migraine-induced mechanical allodynia and show that blocking artemin can reduce migraine-like symptoms, indicating a significant neurotrophic pathway involvement.
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TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Proc Natl Acad Sci U S A
April 2013
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Scraping through the ice: uncovering the role of TRPM8 in cold transduction.
Am J Physiol Regul Integr Comp Physiol
June 2011