Publications by authors named "David Ciufo"
Article Synopsis
- Tendons transmit force from muscles to bones, which is crucial for movement and their development relies on mechanical loading and calcium (Ca) signaling.
- The study focused on the Ca 1.2 voltage-gated Ca channel in tendon biology, revealing that it's highly expressed during tendon development but decreases in adults.
- Results showed that enhancing Ca 1.2 activity leads to larger tendons with increased collagen production and specific growth factors, suggesting that Ca signaling plays a critical role in tendon formation and remodeling.
Article Synopsis
- Tendons are key structures that connect muscles to bones, and their development and healing rely on mechanical loading and calcium (Ca) signaling, though specifics about Ca signaling in tendon cells remain unclear.
- In their study, researchers explored the role of the Ca 1.2 voltage-gated channel in tendon formation, finding it highly expressed during development but reduced in adults.
- Mice engineered to express a gain-of-function Ca 1.2 channel showed larger tendons with increased fibroblast numbers, enhanced collagen formation, and significant changes in extracellular matrix proteins and growth factors related to tendon development.
Objective: (1) To present an effective surgical technique for the treatment of open and high-energy calcaneal fractures with significant soft tissue injuries. (2) To present complications with this technique and to evaluate patient-reported outcomes of staged external fixation followed by delayed reconstruction with open reduction internal fixation (ORIF) and subtalar arthrodesis.
Design: Retrospective case series.
Background: There is limited literature on axial rotation of the ankle or variations in anatomy of the talus. We aim to evaluate the rotational profile of the distal tibia and its relationship to talus morphology, radiographic foot-type, and tibiotalar tilt in arthritic ankles.
Methods: Preoperative imaging was reviewed in 173 consecutive patients with ankle arthritis.
Objectives: To evaluate and compare femoral neck shortening and varus collapse in stable pertrochanteric femur fractures treated with sliding hip screws (SHSs) or cephalomedullary nails (CMNs).
Design: Retrospective review.
Setting: Academic medical center.
Background: Adult acquired flatfoot deformity (AAFD) is a complex and progressive deformity involving the ligamentous structures of the medial peritalar joints. Recent anatomic studies demonstrated that the spring and deltoid ligaments form a greater medial ligament complex, the tibiocalcaneonavicular ligament (TCNL), which provides medial stability to the talonavicular, subtalar, and tibiotalar joints. The aim of this study was to assess the biomechanical effect of a spring ligament tear on the peritalar stability.
View Article and Find Full Text PDFBackground: Many patients undergoing below knee amputations (BKA) return for subsequent unplanned operations, hospital readmission, or postoperative complications. This unplanned medical management negatively impacts both patient outcomes and our healthcare system. This study primarily investigates the risk factors for unplanned reoperation following BKA.
View Article and Find Full Text PDFBackground:: The knee scooter is a commonly used mobility device in the setting of unilateral below-knee immobilization. The bent-knee posture has been shown to decrease venous flow in a seated position, but the knee scooter differs as the patient is weightbearing through the affected extremity. Our goal was to investigate the effects of knee scooter positioning on popliteal venous flow.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the relationship between cephalomedullary nail cutout in trochanteric femur fractures and specific radiographic features, such as lateral wall fractures and malreduction.
- Conducted at an academic medical center, the retrospective review included 362 patients, primarily elderly females, who underwent surgery for low-energy fractures, with follow-up ranging from 3 to 88 months.
- Results showed a 6% incidence of cutouts, significantly associated with lateral wall fractures, neck-shaft malreduction, and residual gapping, indicating both modifiable and nonmodifiable risk factors.
Article Synopsis
- Corneal scarring is a major cause of blindness, and current treatments have limited effectiveness and side effects.
- Researchers tested Rosiglitazone, a drug that targets a specific receptor, on adult cats with induced corneal damage to see if it could reduce scar formation.
- Results showed that Rosiglitazone reduced scar tissue and improved visual clarity, suggesting it could be a promising new treatment for preventing corneal scarring, especially in patients with thin corneas.