Publications by authors named "David Campany-Herrero"
Inhaled tobramycin treatment has been associated with nephrotoxicity in some case reports, but limited data are available about serum levels and its possible systemic absorption in lung transplant recipients (LTR). We conducted a single-center, observational and retrospective study of all adult (>18 years old) LTR treated with inhaled tobramycin for at least 3 days between June 2019 and February 2022. Trough serum levels were collected and >2 μg/mL was considered a high drug level.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the benefits of nebulizing voriconazole for treating fungal lung diseases, highlighting its potential for better lung penetration and fewer side effects compared to traditional methods.
- Researchers conducted a retrospective analysis of ten patients, focusing on the preparation and delivery of a compounded voriconazole solution for nebulization.
- Results indicated that the nebulized solution was well tolerated, with no adverse effects or systemic absorption observed, but further research is required to evaluate its effectiveness.
Article Synopsis
- The study investigates the use of nebulized voriconazole for treating fungal lung diseases, noting its potential benefits like better lung penetration and fewer side effects compared to other delivery methods.
- It involved ten patients (nine adults and one child) who received compounded voriconazole solutions, showing no adverse effects and no drug absorption into the bloodstream.
- The findings suggest nebulized voriconazole could be a viable option, but more research is necessary to evaluate its effectiveness in treating these conditions.
Amphotericin B deoxycolate availability in Spain.
Enferm Infecc Microbiol Clin (Engl Ed)
October 2023
Aims: Several cases of ertapenem-related neurotoxicity have been published in the current literature. However, studies evaluating the ertapenem blood concentration (EBC) as a risk of these adverse events are scarce. We aimed to evaluate the relationship between the trough EBC and the risk of neurological toxicity.
View Article and Find Full Text PDFIntroduction And Objectives: Tocilizumab is an interleukin-6 receptor-blocking agent proposed for the treatment of severe COVID-19; however, limited data are available on their efficacy. The aim of this study was to assess the effect of tocilizumab on the outcomes of patients with COVID-19 pneumonia by using propensity-score-matching (PSM) analysis.
Methods: A retrospective observational analysis of hospitalized COVID-19 adult patients admitted to the Vall d'Hebron Hospital was performed between March and April 2020.
Isavuconazole (ISA) is an alternative treatment for Aspergillus spp. and other fungal infections, but evidence regarding its use in solid organ transplant recipients (SOTR) is scarce. All SOTR who received ISA for treatment of a fungal infection (FI) at our center from December 2017 to January 2021 were included.
View Article and Find Full Text PDFIntroduction And Objectives: Tocilizumab is an interleukin-6 receptor-blocking agent proposed for the treatment of severe COVID-19; however, limited data are available on their efficacy. The aim of this study was to assess the effect of tocilizumab on the outcomes of patients with COVID-19 pneumonia by using propensity-score-matching (PSM) analysis.
Methods: A retrospective observational analysis of hospitalized COVID-19 adult patients admitted to the Vall d'Hebron Hospital was performed between March and April 2020.
/ isolates cause infections with high mortality in lung transplant recipients. Treatment is challenging due to antimicrobial resistance. We describe two cases of / tracheobronchitis in lung transplant recipients successfully treated with nebulized micafungin.
View Article and Find Full Text PDFBackground Tigecycline is a broad-spectrum antibiotic used to treat infections that do not respond to first-line treatments. High-doses and extended treatments are common; therefore, adverse events might be more frequent and severe than those observed in clinical trials. Several case-reports have referred hypofibrinogenemia in patients who received tigecycline.
View Article and Find Full Text PDFObjective: To determine by experimentation whether micafungin and anidulafungin possess physicochemical properties suitable for nebulization.
Method: PH, osmolality, viscosity, density and chloride content were determined by pH monitoring, osmometry, viscometry, densitometry and potentiometry in two samples of different concentrations, 5 and 10 mg/mL each echinocandin. Results: The results obtained for micafungin solution were: pH 5.