Publications by authors named "David C Helfgott"
Immunocompromised patients are susceptible to complications from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The mRNA vaccines BNT162b2 and mRNA-1273 are effective in immunocompetent adults, but have diminished activity in immunocompromised patients. We measured anti-spike SARS-CoV-2 antibody (anti-S) response, avidity, and surrogate neutralizing antibody activity in COVID-19 vaccinated patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
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- Carbapenem-resistant Enterobacteriaceae (CRE) are becoming more common in patients with blood cancers, but there's limited understanding of how they develop in these individuals.
- A study identified 18 cases of bloodstream infections caused by CRE over 3.5 years, with a high mortality rate of 56%, especially among neutropenic patients.
- The research highlights issues such as ineffective initial treatments and delays in administering effective antibiotics, emphasizing the need for better diagnostics and treatment approaches for this at-risk population.