Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female.

Acanthosis nigricans (AN) is a dermatopathy associated with insulin-resistance, drugs, endocrine disorders, chromosomal abnormalities (benign AN), and neoplasia (malignant AN). Malignant AN (MAN) is a rare paraneoplastic skin syndrome most commonly associated with gastric adenocarcinoma and other intra-abdominal malignancies. We report the case of a 28-year-old female with AN associated with obesity, insulin resistance, and endometrial adenocarcinoma.

Imiquimod in the treatment of penile intraepithelial neoplasia: An update.

Penile intraepithelial neoplasia (PIN), or penile squamous cell carcinoma in situ, is a rare disease and may be associated with high morbidity and mortality. In an attempt to avoid surgical intervention, which may result in poor cosmetic and functional outcomes for patients, many non-invasive treatments have been trialled with variable success rates. This review summarises the available literature describing the use of topical imiquimod for PIN.

Cardiac arrest secondary to type 2 Kounis syndrome resulting from urticaria and angioedema.

A 43-year-old man with no cardiac history presented with chest pain followed by cardiac arrest. He was successfully defibrillated and underwent primary percutaneous coronary angioplasty to a culprit coronary artery lesion. He later re-presented with a diffuse urticarial rash and lip swelling, reporting that these symptoms had been present for 4 weeks before his cardiac arrest and voicing concern that a further cardiac arrest may be imminent.

One-fifth of basal cell carcinomas have a morphoeic or partly morphoeic histology: implications for treatment.

A retrospective analysis of the histopathology reports for all first or single basal cell carcinomas (1567) surgically treated over a 13-year period, was undertaken. Basal cell carcinomas classified by standard skin pathology nomenclature were divided into three groups: purely morphoeic basal cell carcinomas, partly morphoeic basal cell carcinomas and non-morphoeic basal cell carcinomas. A morphoeic or partly morphoeic histology was reported in 21.