Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA.

The enantiomers and the cis isomers of two previously studied 4,5-disubstituted oxazolidinones have been synthesized, and their binding to the T-box riboswitch antiterminator model RNA has been investigated in detail. Characterization of ligand affinities and binding site localization indicates that there is little stereospecific discrimination for binding antiterminator RNA alone. This binding similarity between enantiomers is likely due to surface binding, which accommodates ligand conformations that result in comparable ligand-antiterminator contacts.

Ceramic aneurysm clips.

Objective: To design and manufacture an aneurysm clip that incorporates ceramic jaws and a titanium spring, thereby decreasing susceptibility artifact at the aneurysm neck and allowing intra- and/or postoperative magnetic resonance (MR) evaluation.

Methods: A series of aneurysm clips were developed using ceramic jaws and a titanium spring. A corresponding clip applicator with a novel clip-applicator interface was developed to improve ergonomics and visibility during clip placement or removal.