Publications by authors named "David B Zich"
J Microbiol Methods
August 2016
Article Synopsis
- Drug-resistant bacterial infections, particularly from methicillin-resistant Staphylococcus aureus (MRSA), pose a global health threat, prompting the need for new treatment strategies like targeting bacterial virulence factors through anti-virulence approaches.
- Quorum sensing, which regulates virulence in MRSA, serves as a promising target, and this project developed a novel method using ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) to measure the key signaling molecule, auto-inducing peptide I (AIP I), in bacterial cultures.
- The new method showed strong validation results, successfully detecting AIP I at low concentrations and demonstrated that known inhibitor ambuic acid effectively reduces AIP I production in MRSA, offering a promising alternative to existing
