Publications by authors named "David Azzara"
Article Synopsis
- The study investigates how arsenic exposure affects the mouse placenta using single-cell RNA sequencing to uncover changes in gene expression and function across various cell types.
- A key finding is the significant upregulation of the Prap1 gene, which encodes a protein that appears to provide protective effects against arsenic toxicity, particularly in female placental cells.
- The research highlights the potential for understanding how environmental toxins impact fetal development and suggests new strategies for preventing and treating related health issues in mothers and their children.
Lead (Pb) and arsenic (As) are prevalent metal contaminants in the environment. Exposures to these metals are associated with impaired neuronal functions and adverse effects on neurodevelopment in children. However, the molecular mechanisms by which Pb and As impair neuronal functions remain poorly understood.
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