Publications by authors named "David Arntzen"
Article Synopsis
- A 21-year-old female presented with symptoms like fever, sore throat, swollen lymph nodes, and a widespread rash, alongside a history of depression and recent bipolar disorder treatment.
- Lab tests indicated elevated liver enzymes, eosinophilia, and other inflammatory markers, leading to a liver biopsy that suggested drug-induced hepatitis.
- The diagnosis of DRESS (drug reaction with eosinophilia and systemic symptoms) was confirmed, requiring immediate cessation of the suspected medication and treatment with high-dose corticosteroids for recovery.
Background: Defects of articular cartilage are an unsolved problem in orthopaedics. In the present study, we tested the hypothesis that gene transfer of human fibroblast growth factor 2 (FGF-2) via transplantation of encapsulated genetically modified articular chondrocytes stimulates chondrogenesis in cartilage defects in vivo.
Methods: Lapine articular chondrocytes overexpressing a lacZ or a human FGF-2 gene sequence were encapsulated in alginate and further characterized.