Tauroursodeoxycholic acid (TUDCA) in the prevention of total parenteral nutrition-associated liver disease.

Objective: To determine whether tauroursodeoxycholic acid (TUDCA) would prevent or ameliorate the liver injury in neonates treated with total parenteral nutrition (TPN).

Study Design: Eligible infants were enrolled after surgery when serum direct bilirubin (DB) was <2 mg/dL. TUDCA (30 mg/kg/day) was given enterally to 22 subjects.