J Pharmacol Toxicol Methods
January 2008
A Saudi Arabian family is described in which there were 2 siblings with typical features of cerebral xanthomatosis CTX including premature cataracts, xanthomata of the Achilles tendons, neuro-psychiatric disturbances, and atherosclerosis. The 2 patients were homozygous for a point mutation in the mitochondrial 27-hydroxylase gene CYP27A1, OMIM 606530 located in the splice site of intron 6, where G was exchanged for A IVS6+1G>A. Their parents were cousins, 5 siblings were healthy, 2 were heterozygous for the mutation, and one showed the wild-type genotype.
View Article and Find Full Text PDFObjective: To demonstrate whether fluconazole reduces multiple organ failure and mortality in early septic shock (<24 hrs).
Design: A prospective randomized double-blind study.
Setting: A medical and surgical adult intensive care unit in a tertiary referral center.
Study Objective: To describe our initial experience of the perioperative anesthetic care provided to pediatric recipients during living-related liver transplantation.
Design: Cohort review of the perioperative anesthetic care for living-related liver transplantation.
Setting: Tertiary referral and postgraduate teaching hospital.