Publications by authors named "David A Price Evans"
Article Synopsis
- The experiment aimed to test whether intramuscular chromium could help reduce heart and aorta lipid levels and serum cholesterol in cholesterol-rich rabbits.
- A computer-based method assessed the size of lipid deposits, revealing that chromium treatment significantly reduced these deposits and cholesterol levels in the rabbits.
- Although chromium-treated rabbits showed improved heart conditions and continued to gain weight, some liver function tests were abnormal, indicating further research may be needed for effective human atherosclerosis treatment.
A novel computer-based method for the measurement of the lipid "load" in the coronary vessels of rabbits.
J Pharmacol Toxicol Methods
January 2008
Article Synopsis
- This study introduces a novel method that integrates histological and digital techniques to accurately measure fatty deposits in the hearts of cholesterol-fed rabbits.
- The research involved three groups of New Zealand male rabbits, where one group received no treatment, another a cholesterol diet followed by a normal diet with chopped carrots, and the last group received the same but with added cholesterol-lowering medications.
- Results showed a significant increase in fatty deposits in the cholesterol diet group, while the treatment group exhibited a notable reduction in coronary lipid levels, highlighting the efficacy of the combined treatment approach.
- The method developed offers a reliable way to assess coronary lipid deposits, addressing limitations of earlier techniques that primarily focused on aortic lesions.
A Saudi Arabian family is described in which there were 2 siblings with typical features of cerebral xanthomatosis CTX including premature cataracts, xanthomata of the Achilles tendons, neuro-psychiatric disturbances, and atherosclerosis. The 2 patients were homozygous for a point mutation in the mitochondrial 27-hydroxylase gene CYP27A1, OMIM 606530 located in the splice site of intron 6, where G was exchanged for A IVS6+1G>A. Their parents were cousins, 5 siblings were healthy, 2 were heterozygous for the mutation, and one showed the wild-type genotype.
View Article and Find Full Text PDFObjective: To demonstrate whether fluconazole reduces multiple organ failure and mortality in early septic shock (<24 hrs).
Design: A prospective randomized double-blind study.
Setting: A medical and surgical adult intensive care unit in a tertiary referral center.
Study Objective: To describe our initial experience of the perioperative anesthetic care provided to pediatric recipients during living-related liver transplantation.
Design: Cohort review of the perioperative anesthetic care for living-related liver transplantation.
Setting: Tertiary referral and postgraduate teaching hospital.