Publications by authors named "David A Pena Navarro"
Both single and multicellular organisms depend on anti-stress mechanisms that enable them to deal with sudden changes in the environment, including exposure to heat and oxidants. Central to the stress response are dynamic changes in metabolism, such as the transition from the glycolysis to the pentose phosphate pathway-a conserved first-line response to oxidative insults. Here we report a second metabolic adaptation that protects microbial cells in stress situations.
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- Many production processes in the chemical industry can be more efficiently performed by living cells, but they face metabolic limitations.
- To enhance these cells' capabilities, metabolic modeling can identify optimal genetic changes, with Elementary Flux Mode Analysis (EFMA) being a useful tool that doesn’t need a defined cellular goal.
- The authors propose two EFMA-based methods: one for small to medium metabolic networks, and an advanced dual system approach for genome-scale models.